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TABLE 1

Steady-state values from hyperinsulinemic-euglycemic glucose clamps at various insulin infusions

Insulin infusion rate (mU · kg−1 · min−1)Glucose infusion rate (mg · kg−1 · min−1)Plasma insulin (pmol/l)
Fed   
 0 (saline) 337.4 ± 31.4 
 1 2.0 ± 0.3* 356.3 ± 42.8 
 3 12.0 ± 0.3* 638.1 ± 84.0* 
 10 22.0 ± 0.9* 1,985.4 ± 230.4* 
 30 25.5 ± 1.2* 9,666.5 ± 659.6* 
Fasted   
 0 (saline) 270.1 ± 46.1 
 1.5 2.6 ± 0.7* 425.0 ± 96.9 
 3 7.1 ± 0.7* 521.4 ± 50.4* 
 10 18.4 ± 0.9* 1,679.2 ± 130.0* 
Insulin infusion rate (mU · kg−1 · min−1)Glucose infusion rate (mg · kg−1 · min−1)Plasma insulin (pmol/l)
Fed   
 0 (saline) 337.4 ± 31.4 
 1 2.0 ± 0.3* 356.3 ± 42.8 
 3 12.0 ± 0.3* 638.1 ± 84.0* 
 10 22.0 ± 0.9* 1,985.4 ± 230.4* 
 30 25.5 ± 1.2* 9,666.5 ± 659.6* 
Fasted   
 0 (saline) 270.1 ± 46.1 
 1.5 2.6 ± 0.7* 425.0 ± 96.9 
 3 7.1 ± 0.7* 521.4 ± 50.4* 
 10 18.4 ± 0.9* 1,679.2 ± 130.0* 

Data are means ± SE.

*

Significantly different from saline (P < 0.05).

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