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TABLE 5

Type 1 diabetes risk in autoantibody-positive relatives: multivariate analysis

Islet autoantibody characteristics significant in univariate analysisnType 1 diabetes (n)Adjusted HR (95% CI)P
Two or more antibodies 80 37 1.6 (0.6–3.8) 0.32 
IA-2A high titer 47 30 5.4 (1–29) 0.05 
IAA high titer 18 12 1.0 (0.4–2.7) 0.97 
IA-2A subclass 29 22 3.3 (1.4–8.1) 0.008 
IAA subclass 39 19 4.6 (1.5–14) 0.007 
Multiple IA-2A epitopes 34 22 1.2 (0.5–3) 0.70 
IA-2β antibody positive 30 22 1.1 (0.4–3.2) 0.83 
Islet autoantibody characteristics significant in univariate analysisnType 1 diabetes (n)Adjusted HR (95% CI)P
Two or more antibodies 80 37 1.6 (0.6–3.8) 0.32 
IA-2A high titer 47 30 5.4 (1–29) 0.05 
IAA high titer 18 12 1.0 (0.4–2.7) 0.97 
IA-2A subclass 29 22 3.3 (1.4–8.1) 0.008 
IAA subclass 39 19 4.6 (1.5–14) 0.007 
Multiple IA-2A epitopes 34 22 1.2 (0.5–3) 0.70 
IA-2β antibody positive 30 22 1.1 (0.4–3.2) 0.83 
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