Clinical and metabolic characteristics of lean, obese, and diabetic subjects
| . | Lean . | Obese . | Diabetic . |
|---|---|---|---|
| Age (years) | 45 ± 5 | 46 ± 3 | 50 ± 2 |
| BMI (kg/m2) | 24.4 ± 0.6 | 33.4 ± 1.4* | 34.7 ± 1.1* |
| HbA1c (%) | 5.1 ± 0.2 | 5.2 ± 0.2 | 10.1 ± 1.2*† |
| Glucose (mmol/l) | 4.8 ± 0.1 | 5.1 ± 0.1 | 9.4 ± 0.8*† |
| Insulin (pmol/l) | 49 ± 10 | 86 ± 21 | 142 ± 22.8‡ |
| Clamp insulin (pmol/l) | 6,400 ± 600 | 6,108 ± 960 | 4,012 ± 696§‖ |
| Free fatty acids (mmol/l) | 0.36 ± 0.06 | 0.53 ± 0.07 | 0.80 ± 0.10*‖ |
| GDR (mg · kg−1 · min−1) | 13.2 ± 0.9 | 9.8 ± 0.4* | 5.0 ± 0.4*† |
| . | Lean . | Obese . | Diabetic . |
|---|---|---|---|
| Age (years) | 45 ± 5 | 46 ± 3 | 50 ± 2 |
| BMI (kg/m2) | 24.4 ± 0.6 | 33.4 ± 1.4* | 34.7 ± 1.1* |
| HbA1c (%) | 5.1 ± 0.2 | 5.2 ± 0.2 | 10.1 ± 1.2*† |
| Glucose (mmol/l) | 4.8 ± 0.1 | 5.1 ± 0.1 | 9.4 ± 0.8*† |
| Insulin (pmol/l) | 49 ± 10 | 86 ± 21 | 142 ± 22.8‡ |
| Clamp insulin (pmol/l) | 6,400 ± 600 | 6,108 ± 960 | 4,012 ± 696§‖ |
| Free fatty acids (mmol/l) | 0.36 ± 0.06 | 0.53 ± 0.07 | 0.80 ± 0.10*‖ |
| GDR (mg · kg−1 · min−1) | 13.2 ± 0.9 | 9.8 ± 0.4* | 5.0 ± 0.4*† |
Data are means ± SD. The study comprised 15 lean (all male), 16 obese (all male), and 21 obese type 2 diabetic (18 male and 3 female) subjects. Glucose, insulin, and free fatty acids were measured after an overnight fast.
P < 0.001 vs. lean;
P < 0.001 vs. obese;
P < 0.01 vs. lean;
P < 0.05 vs. lean;
P < 0.05 vs. obese.