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TABLE 2

Associations between SNPs in adiponectin gene and risk of type 2 diabetes

Case subjectsControl subjectsUnadjusted ORMultivariate OR*
SNP-11365 C/C 357 (55.6) 557 (56.0) 1.0 1.0 
 C/G 244 (38.0) 379 (38.1) 1.00 (0.81–1.23) 1.01 (0.81–1.27) 
 G/G 41 (6.4) 59 (5.9) 1.08 (0.71–1.64) 1.02 (0.65–1.59) 
SNP-4034 A/A 292 (45.5) 418 (42.0) 1.0 1.0 
 A/C 280 (43.6) 439 (44.1) 0.92 (0.74–1.13) 0.96 (0.76–1.20) 
 C/C 70 (10.9) 138 (13.9) 0.73 (0.53–1.01) 0.70 (0.50–0.99) 
SNP-3964 A/A 440 (68.5) 633 (63.6) 1.0 1.0 
 A/G 177 (27.6) 331 (33.3) 0.78 (0.63–0.97) 0.79 (0.62–1.00) 
 G/G 25 (3.9) 31 (3.1) 1.16 (0.68–2.00) 1.20 (0.67–2.13) 
SNP + 45 T/T 518 (80.7) 785 (78.9) 1.0 1.0 
 T/G + G/G 124 (19.3) 210 (21.1) 0.90 (0.70–1.15) 0.91 (0.70–1.19) 
SNP + 276 G/G 322 (50.2) 523 (52.6) 1.0 1.0 
 G/T 266 (41.4) 399 (40.1) 1.08 (0.88–1.34) 1.16 (0.93–1.45) 
 T/T 54 (8.4) 73 (7.3) 1.20 (0.82–1.75) 1.22 (0.81–1.82) 
Case subjectsControl subjectsUnadjusted ORMultivariate OR*
SNP-11365 C/C 357 (55.6) 557 (56.0) 1.0 1.0 
 C/G 244 (38.0) 379 (38.1) 1.00 (0.81–1.23) 1.01 (0.81–1.27) 
 G/G 41 (6.4) 59 (5.9) 1.08 (0.71–1.64) 1.02 (0.65–1.59) 
SNP-4034 A/A 292 (45.5) 418 (42.0) 1.0 1.0 
 A/C 280 (43.6) 439 (44.1) 0.92 (0.74–1.13) 0.96 (0.76–1.20) 
 C/C 70 (10.9) 138 (13.9) 0.73 (0.53–1.01) 0.70 (0.50–0.99) 
SNP-3964 A/A 440 (68.5) 633 (63.6) 1.0 1.0 
 A/G 177 (27.6) 331 (33.3) 0.78 (0.63–0.97) 0.79 (0.62–1.00) 
 G/G 25 (3.9) 31 (3.1) 1.16 (0.68–2.00) 1.20 (0.67–2.13) 
SNP + 45 T/T 518 (80.7) 785 (78.9) 1.0 1.0 
 T/G + G/G 124 (19.3) 210 (21.1) 0.90 (0.70–1.15) 0.91 (0.70–1.19) 
SNP + 276 G/G 322 (50.2) 523 (52.6) 1.0 1.0 
 G/T 266 (41.4) 399 (40.1) 1.08 (0.88–1.34) 1.16 (0.93–1.45) 
 T/T 54 (8.4) 73 (7.3) 1.20 (0.82–1.75) 1.22 (0.81–1.82) 

Data are n (%) or OR (95% CI).

*

Adjusted for age (5-year categories), alcohol consumption (nondrinkers, 0–4.9, 5–10, or >10 g/day), physical activity (quintiles of metabolic equivalent hours/week), smoking (never, past, and current smoker of 1–14, 15–24, and ≥25 cigarettes/day), and BMI (<23, 23–24.9, 25–29.9, 30–34.9, and ≥35 kg/m2).

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