Associations between SNPs in adiponectin gene and risk of type 2 diabetes
| . | . | Case subjects . | Control subjects . | Unadjusted OR . | Multivariate OR* . |
|---|---|---|---|---|---|
| SNP-11365 | C/C | 357 (55.6) | 557 (56.0) | 1.0 | 1.0 |
| C/G | 244 (38.0) | 379 (38.1) | 1.00 (0.81–1.23) | 1.01 (0.81–1.27) | |
| G/G | 41 (6.4) | 59 (5.9) | 1.08 (0.71–1.64) | 1.02 (0.65–1.59) | |
| SNP-4034 | A/A | 292 (45.5) | 418 (42.0) | 1.0 | 1.0 |
| A/C | 280 (43.6) | 439 (44.1) | 0.92 (0.74–1.13) | 0.96 (0.76–1.20) | |
| C/C | 70 (10.9) | 138 (13.9) | 0.73 (0.53–1.01) | 0.70 (0.50–0.99) | |
| SNP-3964 | A/A | 440 (68.5) | 633 (63.6) | 1.0 | 1.0 |
| A/G | 177 (27.6) | 331 (33.3) | 0.78 (0.63–0.97) | 0.79 (0.62–1.00) | |
| G/G | 25 (3.9) | 31 (3.1) | 1.16 (0.68–2.00) | 1.20 (0.67–2.13) | |
| SNP + 45 | T/T | 518 (80.7) | 785 (78.9) | 1.0 | 1.0 |
| T/G + G/G | 124 (19.3) | 210 (21.1) | 0.90 (0.70–1.15) | 0.91 (0.70–1.19) | |
| SNP + 276 | G/G | 322 (50.2) | 523 (52.6) | 1.0 | 1.0 |
| G/T | 266 (41.4) | 399 (40.1) | 1.08 (0.88–1.34) | 1.16 (0.93–1.45) | |
| T/T | 54 (8.4) | 73 (7.3) | 1.20 (0.82–1.75) | 1.22 (0.81–1.82) |
| . | . | Case subjects . | Control subjects . | Unadjusted OR . | Multivariate OR* . |
|---|---|---|---|---|---|
| SNP-11365 | C/C | 357 (55.6) | 557 (56.0) | 1.0 | 1.0 |
| C/G | 244 (38.0) | 379 (38.1) | 1.00 (0.81–1.23) | 1.01 (0.81–1.27) | |
| G/G | 41 (6.4) | 59 (5.9) | 1.08 (0.71–1.64) | 1.02 (0.65–1.59) | |
| SNP-4034 | A/A | 292 (45.5) | 418 (42.0) | 1.0 | 1.0 |
| A/C | 280 (43.6) | 439 (44.1) | 0.92 (0.74–1.13) | 0.96 (0.76–1.20) | |
| C/C | 70 (10.9) | 138 (13.9) | 0.73 (0.53–1.01) | 0.70 (0.50–0.99) | |
| SNP-3964 | A/A | 440 (68.5) | 633 (63.6) | 1.0 | 1.0 |
| A/G | 177 (27.6) | 331 (33.3) | 0.78 (0.63–0.97) | 0.79 (0.62–1.00) | |
| G/G | 25 (3.9) | 31 (3.1) | 1.16 (0.68–2.00) | 1.20 (0.67–2.13) | |
| SNP + 45 | T/T | 518 (80.7) | 785 (78.9) | 1.0 | 1.0 |
| T/G + G/G | 124 (19.3) | 210 (21.1) | 0.90 (0.70–1.15) | 0.91 (0.70–1.19) | |
| SNP + 276 | G/G | 322 (50.2) | 523 (52.6) | 1.0 | 1.0 |
| G/T | 266 (41.4) | 399 (40.1) | 1.08 (0.88–1.34) | 1.16 (0.93–1.45) | |
| T/T | 54 (8.4) | 73 (7.3) | 1.20 (0.82–1.75) | 1.22 (0.81–1.82) |
Data are n (%) or OR (95% CI).
Adjusted for age (5-year categories), alcohol consumption (nondrinkers, 0–4.9, 5–10, or >10 g/day), physical activity (quintiles of metabolic equivalent hours/week), smoking (never, past, and current smoker of 1–14, 15–24, and ≥25 cigarettes/day), and BMI (<23, 23–24.9, 25–29.9, 30–34.9, and ≥35 kg/m2).