The association between adiponectin +276 and risk of type 2 diabetes according to PPARγ genotype and obesity
| . | Case subjects . | Control subjects . | OR (95% CI) . | P for interaction . |
|---|---|---|---|---|
| PPARγ Pro/Pro | ||||
| SNP +276 | ||||
| G/G | 269 (52.2) | 392 (52.6) | 1.0* | |
| G/T + T/T | 246 (47.8) | 354 (47.5) | 1.09 (0.86–1.39)* | 0.14 |
| PPARγ Ala | ||||
| SNP +276 | ||||
| G/G | 51 (40.8) | 127 (52.1) | 1.0* | |
| G/T + T/T | 74 (59.2) | 117 (48.0) | 1.69 (1.04–2.75)* | |
| BMI <30 kg/m2 | ||||
| SNP +276 | ||||
| G/G | 172 (51.5) | 372 (51.5) | 1.0† | |
| G/T + T/T | 161 (48.4) | 350 (48.5) | 1.04 (0.79–1.36)† | 0.10 |
| BMI ≥30 kg/m2 | ||||
| SNP +276 | ||||
| G/G | 143 (48.6) | 143 (56.1) | 1.0† | |
| G/T + T/T | 151 (51.4) | 112 (43.9) | 1.46 (1.03–1.08)† |
| . | Case subjects . | Control subjects . | OR (95% CI) . | P for interaction . |
|---|---|---|---|---|
| PPARγ Pro/Pro | ||||
| SNP +276 | ||||
| G/G | 269 (52.2) | 392 (52.6) | 1.0* | |
| G/T + T/T | 246 (47.8) | 354 (47.5) | 1.09 (0.86–1.39)* | 0.14 |
| PPARγ Ala | ||||
| SNP +276 | ||||
| G/G | 51 (40.8) | 127 (52.1) | 1.0* | |
| G/T + T/T | 74 (59.2) | 117 (48.0) | 1.69 (1.04–2.75)* | |
| BMI <30 kg/m2 | ||||
| SNP +276 | ||||
| G/G | 172 (51.5) | 372 (51.5) | 1.0† | |
| G/T + T/T | 161 (48.4) | 350 (48.5) | 1.04 (0.79–1.36)† | 0.10 |
| BMI ≥30 kg/m2 | ||||
| SNP +276 | ||||
| G/G | 143 (48.6) | 143 (56.1) | 1.0† | |
| G/T + T/T | 151 (51.4) | 112 (43.9) | 1.46 (1.03–1.08)† |
Data are n (%) unless otherwise indicated. The number of case and control subjects in these analyses was less than the overall study due to missing data on PPARγ genotype or obesity.
Adjusted for age (5-year categories), alcohol consumption (nondrinkers, 0–4.9, 5–10, or ≥10 g/day), physical activity (quintiles of metabolic equivalent hours/week), smoking (never, past, and current smoker of 1–14, 15–24, and ≥25 cigarettes/day), and BMI (<23, 23–24.9, 25–29.9, 30–34.9, and ≥35 kg/m2).
Adjusted for age (5-year categories), alcohol consumption (nondrinkers, 0–4.9, 5–10, or ≥10 g/day), physical activity (quintiles of metabolic equivalent hours/week), and smoking (never, past, and current smoker of 1–14, 15–24, and ≥25 cigarettes/day).