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TABLE 3

The association between adiponectin +276 and risk of type 2 diabetes according to PPARγ genotype and obesity

Case subjectsControl subjectsOR (95% CI)P for interaction
PPARγ Pro/Pro     
 SNP +276     
  G/G 269 (52.2) 392 (52.6) 1.0*  
  G/T + T/T 246 (47.8) 354 (47.5) 1.09 (0.86–1.39)* 0.14 
PPARγ Ala     
 SNP +276     
  G/G 51 (40.8) 127 (52.1) 1.0*  
  G/T + T/T 74 (59.2) 117 (48.0) 1.69 (1.04–2.75)*  
BMI <30 kg/m2     
 SNP +276     
  G/G 172 (51.5) 372 (51.5) 1.0  
  G/T + T/T 161 (48.4) 350 (48.5) 1.04 (0.79–1.36) 0.10 
BMI ≥30 kg/m2     
 SNP +276     
  G/G 143 (48.6) 143 (56.1) 1.0  
  G/T + T/T 151 (51.4) 112 (43.9) 1.46 (1.03–1.08)  
Case subjectsControl subjectsOR (95% CI)P for interaction
PPARγ Pro/Pro     
 SNP +276     
  G/G 269 (52.2) 392 (52.6) 1.0*  
  G/T + T/T 246 (47.8) 354 (47.5) 1.09 (0.86–1.39)* 0.14 
PPARγ Ala     
 SNP +276     
  G/G 51 (40.8) 127 (52.1) 1.0*  
  G/T + T/T 74 (59.2) 117 (48.0) 1.69 (1.04–2.75)*  
BMI <30 kg/m2     
 SNP +276     
  G/G 172 (51.5) 372 (51.5) 1.0  
  G/T + T/T 161 (48.4) 350 (48.5) 1.04 (0.79–1.36) 0.10 
BMI ≥30 kg/m2     
 SNP +276     
  G/G 143 (48.6) 143 (56.1) 1.0  
  G/T + T/T 151 (51.4) 112 (43.9) 1.46 (1.03–1.08)  

Data are n (%) unless otherwise indicated. The number of case and control subjects in these analyses was less than the overall study due to missing data on PPARγ genotype or obesity.

*

Adjusted for age (5-year categories), alcohol consumption (nondrinkers, 0–4.9, 5–10, or ≥10 g/day), physical activity (quintiles of metabolic equivalent hours/week), smoking (never, past, and current smoker of 1–14, 15–24, and ≥25 cigarettes/day), and BMI (<23, 23–24.9, 25–29.9, 30–34.9, and ≥35 kg/m2).

Adjusted for age (5-year categories), alcohol consumption (nondrinkers, 0–4.9, 5–10, or ≥10 g/day), physical activity (quintiles of metabolic equivalent hours/week), and smoking (never, past, and current smoker of 1–14, 15–24, and ≥25 cigarettes/day).

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