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TABLE 1

cGMP content in DRGs of control and diabetic rats

In vivo
Ex vivo
cGMP/protein (fmol/mg) ncGMP/protein (fmol/mg) ncGMP/protein (fmol/mg) n
Diabetic rats    
  LY333531 treated 148.47 ± 9.84* 81.16 ± 1.27
  Untreated 91.02 ± 6.017 89.24 ± 7.2575.73 ± 0.846 
  l-arginine treated  113.80 ± 3.845  
Control rats    
  LY333531 treated 123.65 ± 4.447  76.83 ± 0.596 
  Untreated 124.72 ± 7.817 116.77 ± 3.095 76.47 ± 1.076 
  l-arginine treated  126.69 ± 6.375  
In vivo
Ex vivo
cGMP/protein (fmol/mg) ncGMP/protein (fmol/mg) ncGMP/protein (fmol/mg) n
Diabetic rats    
  LY333531 treated 148.47 ± 9.84* 81.16 ± 1.27
  Untreated 91.02 ± 6.017 89.24 ± 7.2575.73 ± 0.846 
  l-arginine treated  113.80 ± 3.845  
Control rats    
  LY333531 treated 123.65 ± 4.447  76.83 ± 0.596 
  Untreated 124.72 ± 7.817 116.77 ± 3.095 76.47 ± 1.076 
  l-arginine treated  126.69 ± 6.375  

Data are means ± SE.

*

P < 0.01,

P < 0.05 compared with untreated diabetic rats.

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