American Diabetes Association

TABLE 1

Characteristics of the HNF-1α mutations segregating with diabetes in the 13 MODY3 families

Family ID no.	Mutation	No. of carriers with diabetes/IGT	Age (years) at onset
Family ID no.	Mutation	No. of carriers with diabetes/IGT			Mean	Range
01	E24fsdelGA	4/−	20	14–28
02	L44fsdelC	4/−	11	10–13
03	L107R	16/−	19	9–37
04	A116V	8/−	29	13–48
05	R131W	9/1	21	11–41
06	Q146K	5/−	15	10–24
	H147R
07	E240Q	4/2	25	19–35
08	R272H	6/−	22	17–34
09	P291fsdelC	3/−	13	10–18
10	P291fsinsC	13/−	20	8–48
11	P291fsinsC	−/4	—	—
12	P379fsdelCT	6/−	19	13–26
13	A443fsdelCA	9/2	31	16–49
Total		87/9	21	8–49

Family ID no.	Mutation	No. of carriers with diabetes/IGT	Age (years) at onset
Family ID no.	Mutation	No. of carriers with diabetes/IGT			Mean	Range
01	E24fsdelGA	4/−	20	14–28
02	L44fsdelC	4/−	11	10–13
03	L107R	16/−	19	9–37
04	A116V	8/−	29	13–48
05	R131W	9/1	21	11–41
06	Q146K	5/−	15	10–24
	H147R
07	E240Q	4/2	25	19–35
08	R272H	6/−	22	17–34
09	P291fsdelC	3/−	13	10–18
10	P291fsinsC	13/−	20	8–48
11	P291fsinsC	−/4	—	—
12	P379fsdelCT	6/−	19	13–26
13	A443fsdelCA	9/2	31	16–49
Total		87/9	21	8–49