Chromosomal locations of QTLs mapped in the LGXSM RI strain set on a high- and low-fat diet
| Chromosome 1 | |
| 296–478 | Renal; shadow: tail, {spleen}*, trig† |
| 74–415 | Insulin; shadow: totfat, renal, mesen, ing, leptin, necwt, chol, tail |
| 48–103 | Totfat, repro, renal, mesen, ing, leptin, necwt, chol, tail; shadow: adult‡, {kidney} |
| 196–507 | Chol, heart; shadow: totfat, repro, renal, mesen, necwt, trig |
| 113–155 | Insulin; shadow: {AUC20}♂, kidney, heart, spleen |
| Chromosome 2 | |
| 1–119 | {Kidney}, adult, shadow: {AUC20} |
| 370–409 | Shadow: AUC20, mesen, {kidney}, {trig}♀ |
| 412–265 | Shadow: totfat, repro, renal, mesen, ing, leptin, necwt, adult, chol |
| Chromosome 3 | |
| 60–167 | Mesen, necwt, chol; shadow: totfat, renal |
| 182–106 | {Trig}; shadow: adult, heart, {kidney}, {tail} |
| 106–111 | Spleen; shadow: totfat, repro, {chol} |
| Chromosome 4 | |
| 235–89 | Repro; shadow: totfat, renal, {G020}, {AUC20} |
| 133–135 | Shadow: {G020}♂, {liver} |
| 332–203 | Shadow: renal, mesen, {tail} |
| 148–150 | Shadow: spleen, {FFA} |
| Chromosome 5 | |
| 47–352 | {Kidney}; shadow: totfat, renal, mesen, leptin, chol, {spleen} |
| 267–188 | {Trig}; shadow: {spleen}, |
| 168–169 | {FFA} |
| Chromosome 6 | |
| 236–186 | {G020}, {AUC20}; shadow: spleen, {tail} |
| 209–14 | FFA, tail; shadow: {adult}, trig |
| 198–201 | Shadow: {mesen}, {leptin}, kidney, spleen, tail |
| Chromosome 7 | |
| 21–346 | Heart; shadow: {chol}, {trig}, {FFA}♀, spleen |
| S1–281 | Shadow: kidney |
| 238-S4 | Mesen, adult, tail; shadow: totfat, repro, renal, ing, leptin, necwt |
| Chromosome8 | |
| 58–80 | {Spleen}; shadow: {trig}, {kidney} |
| 312–56 | {Totfat}, {repro}, {renal}, {mesen}, {ing}, {leptin}, {necwt}; shadow: {adult}♀, trig, {tail} |
| Chromosome 9 | |
| 218–289 | {FFA}; shadow: {trig}, {chol} |
| 266–267 | Shadow: {adult}, tail |
| 201–19 | Shadow: {totfat}, {repro}, {renal}, {mesen}, {ing}, {leptin}, {necwt}, {heart} |
| Chromosome 10 | |
| 213–65 | Shadow: {trig}, {FFA}♀, tail♂ |
| 295–305 | Totfat, repro, renal, mesen, ing, necwt, liver, heart; shadow: kidney, spleen, tail |
| Chromosome 11 | |
| 71–173 | {Trig}; shadow: G020♂, AUC20, {FFA}, spleen |
| 349–41 | Totfat; shadow: repro, mesen, ing, necwt, tail |
| 285–48 | {Liver}, kidney; shadow: {G020}♂, {AUC20} |
| Chromosome 12 | |
| 145–153 | {Adult}, {chol}; shadow: {totfat}, {mesen}, {ing}, {necwt} |
| 2–6 | Spleen, heart; shadow: totfat, repro, renal, kidney, tail |
| 231-S2 | Adult; shadow: totfat, renal, mesen, ing, necwt, chol, liver |
| Chromosome 13 | |
| 1–134 | Liver |
| 207–64 | Chol, trig; shadow: totfat, renal, mesen, ing, leptin, necwt♀, spleen, tail |
| 7–144 | Kidney |
| 147–35 | Shadow: totfat, repro, renal, mesen, necwt, chol, heart |
| Chromosome 14 | |
| S1–266 | {FFA}, kidney; shadow: spleen |
| Chromosome 15 | |
| 13-S2 | {Heart}; shadow: tail |
| 203–66 | Shadow: {totfat}, {repro}, {renal}, {mesen}, {adult}♀, trig |
| 2–42 | {Chol}, {spleen}; shadow: G020, AUC20 |
| Chromosome 16 | |
| 28–152 | {Necwt}♀; shadow: {totfat}, {renal}♀, {mesen}, {ing}, {leptin}, {liver}, {spleen}, {kidney}, {tail}, {AUC20} |
| Chromosome 17 | |
| 19–115 | Kidney, adult, chol; shadow: totfat, repro, renal, mesen, ing, leptin, necwt, insulin, {AUC20}, liver |
| Chromosome 18 | |
| 64–94 | Shadow: {trig}, liver |
| 17–213 | Totfat, ing, leptin; shadow: repro, mesen, necwt, chol♀, tail |
| Chromosome 19 | |
| 43–16 | G020♂, AUC20, liver; shadow: kidney, spleen |
| 111–137 | Shadow: repro, tail |
| Chromosome X | |
| 55–10 | {G020}, {AUC20}; shadow: trig, kidney |
| 121–186 | {Totfat}♀, {repro}♀, {renal}♀, {mesen}♀, {leptin}♀, {necwt}, {chol}♀, {insulin}, {liver}, {spleen}; shadow: {ing}, {adult}♀ |
| Chromosome 1 | |
| 296–478 | Renal; shadow: tail, {spleen}*, trig† |
| 74–415 | Insulin; shadow: totfat, renal, mesen, ing, leptin, necwt, chol, tail |
| 48–103 | Totfat, repro, renal, mesen, ing, leptin, necwt, chol, tail; shadow: adult‡, {kidney} |
| 196–507 | Chol, heart; shadow: totfat, repro, renal, mesen, necwt, trig |
| 113–155 | Insulin; shadow: {AUC20}♂, kidney, heart, spleen |
| Chromosome 2 | |
| 1–119 | {Kidney}, adult, shadow: {AUC20} |
| 370–409 | Shadow: AUC20, mesen, {kidney}, {trig}♀ |
| 412–265 | Shadow: totfat, repro, renal, mesen, ing, leptin, necwt, adult, chol |
| Chromosome 3 | |
| 60–167 | Mesen, necwt, chol; shadow: totfat, renal |
| 182–106 | {Trig}; shadow: adult, heart, {kidney}, {tail} |
| 106–111 | Spleen; shadow: totfat, repro, {chol} |
| Chromosome 4 | |
| 235–89 | Repro; shadow: totfat, renal, {G020}, {AUC20} |
| 133–135 | Shadow: {G020}♂, {liver} |
| 332–203 | Shadow: renal, mesen, {tail} |
| 148–150 | Shadow: spleen, {FFA} |
| Chromosome 5 | |
| 47–352 | {Kidney}; shadow: totfat, renal, mesen, leptin, chol, {spleen} |
| 267–188 | {Trig}; shadow: {spleen}, |
| 168–169 | {FFA} |
| Chromosome 6 | |
| 236–186 | {G020}, {AUC20}; shadow: spleen, {tail} |
| 209–14 | FFA, tail; shadow: {adult}, trig |
| 198–201 | Shadow: {mesen}, {leptin}, kidney, spleen, tail |
| Chromosome 7 | |
| 21–346 | Heart; shadow: {chol}, {trig}, {FFA}♀, spleen |
| S1–281 | Shadow: kidney |
| 238-S4 | Mesen, adult, tail; shadow: totfat, repro, renal, ing, leptin, necwt |
| Chromosome8 | |
| 58–80 | {Spleen}; shadow: {trig}, {kidney} |
| 312–56 | {Totfat}, {repro}, {renal}, {mesen}, {ing}, {leptin}, {necwt}; shadow: {adult}♀, trig, {tail} |
| Chromosome 9 | |
| 218–289 | {FFA}; shadow: {trig}, {chol} |
| 266–267 | Shadow: {adult}, tail |
| 201–19 | Shadow: {totfat}, {repro}, {renal}, {mesen}, {ing}, {leptin}, {necwt}, {heart} |
| Chromosome 10 | |
| 213–65 | Shadow: {trig}, {FFA}♀, tail♂ |
| 295–305 | Totfat, repro, renal, mesen, ing, necwt, liver, heart; shadow: kidney, spleen, tail |
| Chromosome 11 | |
| 71–173 | {Trig}; shadow: G020♂, AUC20, {FFA}, spleen |
| 349–41 | Totfat; shadow: repro, mesen, ing, necwt, tail |
| 285–48 | {Liver}, kidney; shadow: {G020}♂, {AUC20} |
| Chromosome 12 | |
| 145–153 | {Adult}, {chol}; shadow: {totfat}, {mesen}, {ing}, {necwt} |
| 2–6 | Spleen, heart; shadow: totfat, repro, renal, kidney, tail |
| 231-S2 | Adult; shadow: totfat, renal, mesen, ing, necwt, chol, liver |
| Chromosome 13 | |
| 1–134 | Liver |
| 207–64 | Chol, trig; shadow: totfat, renal, mesen, ing, leptin, necwt♀, spleen, tail |
| 7–144 | Kidney |
| 147–35 | Shadow: totfat, repro, renal, mesen, necwt, chol, heart |
| Chromosome 14 | |
| S1–266 | {FFA}, kidney; shadow: spleen |
| Chromosome 15 | |
| 13-S2 | {Heart}; shadow: tail |
| 203–66 | Shadow: {totfat}, {repro}, {renal}, {mesen}, {adult}♀, trig |
| 2–42 | {Chol}, {spleen}; shadow: G020, AUC20 |
| Chromosome 16 | |
| 28–152 | {Necwt}♀; shadow: {totfat}, {renal}♀, {mesen}, {ing}, {leptin}, {liver}, {spleen}, {kidney}, {tail}, {AUC20} |
| Chromosome 17 | |
| 19–115 | Kidney, adult, chol; shadow: totfat, repro, renal, mesen, ing, leptin, necwt, insulin, {AUC20}, liver |
| Chromosome 18 | |
| 64–94 | Shadow: {trig}, liver |
| 17–213 | Totfat, ing, leptin; shadow: repro, mesen, necwt, chol♀, tail |
| Chromosome 19 | |
| 43–16 | G020♂, AUC20, liver; shadow: kidney, spleen |
| 111–137 | Shadow: repro, tail |
| Chromosome X | |
| 55–10 | {G020}, {AUC20}; shadow: trig, kidney |
| 121–186 | {Totfat}♀, {repro}♀, {renal}♀, {mesen}♀, {leptin}♀, {necwt}, {chol}♀, {insulin}, {liver}, {spleen}; shadow: {ing}, {adult}♀ |
Chromosomal locations are identified by markers spanning support intervals. Marker names are DXMitY, where X is the chromosome number and Y is the marker number given in the table. QTLs are listed first followed by potential shadow QTLs (shadow). Trait designations are given in the note indicated with an asterisk. Underlined traits are rated as genome-wide significant QTLs, while traits not underlined should be considered as suggestive QTLs.
No parentheses for QTLs where the LG/J allele leads to higher trait values and {} enclose QTLs where the SM/J allele leads to higher values.
Adult = growth from 10–20 weeks.
Italic font indicates that the QTL is diet dependent, only being apparent on a high-fat diet.
♂, male-specific QTL; ♀, female-specific QTL. AUC20, area under glucose tolerance curve at 20 weeks; chol, cholesterol level; FFA, free fatty acid level; G020, fasting glucose level at 20 weeks; heart, heart weight; ing, inguinal fat depot weight; insulin, fasting insulin level at 20 weeks; kidney, kidney weight; leptin, fasting leptin level at 20 weeks; liver, liver weight; mesen, mesenteric fat depot weight; necwt, body weight at necropsy; renal, renal fat depot weight; repro, reproductive fat depot weight; spleen, spleen weight; tail, tail length; totfat, sum of the four fat depots; trig, triglyceride levels.