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TABLE 1

Characteristics of patients in the cross-sectional (lean/obese) and weight loss (before/after) studies

Cross-sectional study
Weight loss study
LeanObeseBeforeAfter
n 20 20 17 17 
Age (years) 57 ± 1 59 ± 1 59 ± 2 59 ± 2 
BMI (kg/m223.5 ± 0.4 38.3 ± 0.7* 33.1 ± 1.1 31.3 ± 1.0 
Waist circumference (cm) 76 ± 1 109 ± 2* 101 ± 3 97 ± 3 
Daytime ambulatory blood pressure (mmHg)     
    Systolic 127 ± 4 136 ± 3* 137 ± 3 131 ± 2 
    Diastolic 77 ± 2 80 ± 2 82 ± 2 80 ± 1 
Mean daily heart rate (bpm) 76 ± 2 82 ± 2* 82 ± 3 80 ± 3 
Cholesterol (mmol/l)     
    Total 5.4 ± 0.2 5.6 ± 0.2 5.7 ± 0.3 5.5 ± 0.3 
    HDL 1.5 ± 0.1 1.2 ± 0.1* 1.7 ± 0.1 1.6 ± 0.1 
    LDL 3.5 ± 0.2 3.8 ± 0.2 3.5 ± 0.2 3.3 ± 0.3 
Triglycerides (mmol/l) 1.0 ± 0.1 1.5 ± 0.2* 1.2 ± 0.1 1.3 ± 0.2 
Glucose (mmol/l) 4.9 ± 0.1 5.5 ± 0.1* 5.7 ± 0.2 5.7 ± 0.2 
Insulin (μU/l) 2.9 ± 0.4 8.2 ± 0.8* 4.8 ± 0.9 3.9 ± 0.7 
Cross-sectional study
Weight loss study
LeanObeseBeforeAfter
n 20 20 17 17 
Age (years) 57 ± 1 59 ± 1 59 ± 2 59 ± 2 
BMI (kg/m223.5 ± 0.4 38.3 ± 0.7* 33.1 ± 1.1 31.3 ± 1.0 
Waist circumference (cm) 76 ± 1 109 ± 2* 101 ± 3 97 ± 3 
Daytime ambulatory blood pressure (mmHg)     
    Systolic 127 ± 4 136 ± 3* 137 ± 3 131 ± 2 
    Diastolic 77 ± 2 80 ± 2 82 ± 2 80 ± 1 
Mean daily heart rate (bpm) 76 ± 2 82 ± 2* 82 ± 3 80 ± 3 
Cholesterol (mmol/l)     
    Total 5.4 ± 0.2 5.6 ± 0.2 5.7 ± 0.3 5.5 ± 0.3 
    HDL 1.5 ± 0.1 1.2 ± 0.1* 1.7 ± 0.1 1.6 ± 0.1 
    LDL 3.5 ± 0.2 3.8 ± 0.2 3.5 ± 0.2 3.3 ± 0.3 
Triglycerides (mmol/l) 1.0 ± 0.1 1.5 ± 0.2* 1.2 ± 0.1 1.3 ± 0.2 
Glucose (mmol/l) 4.9 ± 0.1 5.5 ± 0.1* 5.7 ± 0.2 5.7 ± 0.2 
Insulin (μU/l) 2.9 ± 0.4 8.2 ± 0.8* 4.8 ± 0.9 3.9 ± 0.7 

Data are means ± SE. Group comparison by Student’s t test for independent samples (cross-sectional study) or by t test for paired samples (weight loss study).

*

P < 0.05 vs. lean;

P < 0.05 vs. baseline.

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