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TABLE 1

The effects of TZDs on insulin secretion and glucose-stimulated insulin secretion

ModelPlasma
Insulin secretionGlucose-stimulated insulin secretionReference
GlucoseInsulin
HIT-T15 cells   Increased insulin secretion in 11 mmol/l glucose  38  
Primary islets from humans   No change No change 30  
Primary islets from ZDF rats   Decrease Increase 39  
Type 2 diabetic humans Decrease Decrease Decrease Increase 4  
db/db mice Decrease Increase* Increased intracellular insulin content of β-cells  35  
db/db mice Decrease No change Increased intracellular insulin content of β-cells  37  
ob/ob mice Decrease Decrease  Increase 34  
KK mice Decrease Decrease  Increase 34  
ZDF rats Decrease Decrease Decrease, increased insulin transcription Increase 5,33,34,36,40  
ModelPlasma
Insulin secretionGlucose-stimulated insulin secretionReference
GlucoseInsulin
HIT-T15 cells   Increased insulin secretion in 11 mmol/l glucose  38  
Primary islets from humans   No change No change 30  
Primary islets from ZDF rats   Decrease Increase 39  
Type 2 diabetic humans Decrease Decrease Decrease Increase 4  
db/db mice Decrease Increase* Increased intracellular insulin content of β-cells  35  
db/db mice Decrease No change Increased intracellular insulin content of β-cells  37  
ob/ob mice Decrease Decrease  Increase 34  
KK mice Decrease Decrease  Increase 34  
ZDF rats Decrease Decrease Decrease, increased insulin transcription Increase 5,33,34,36,40  
*

NS.

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