American Diabetes Association

Skip to Main Content

TABLE 1

The effects of TZDs on insulin secretion and glucose-stimulated insulin secretion

Model	Plasma			Insulin secretion	Glucose-stimulated insulin secretion	Reference
Model		Glucose	Insulin	Insulin secretion	Glucose-stimulated insulin secretion	Reference
HIT-T15 cells			Increased insulin secretion in 11 mmol/l glucose		38
Primary islets from humans			No change	No change	30
Primary islets from ZDF rats			Decrease	Increase	39
Type 2 diabetic humans	Decrease	Decrease	Decrease	Increase	4
db/db mice	Decrease	Increase^*	Increased intracellular insulin content of β-cells		35
db/db mice	Decrease	No change	Increased intracellular insulin content of β-cells		37
ob/ob mice	Decrease	Decrease		Increase	34
KK mice	Decrease	Decrease		Increase	34
ZDF rats	Decrease	Decrease	Decrease, increased insulin transcription	Increase	5,33,34,36,40

Model	Plasma			Insulin secretion	Glucose-stimulated insulin secretion	Reference
Model		Glucose	Insulin	Insulin secretion	Glucose-stimulated insulin secretion	Reference
HIT-T15 cells			Increased insulin secretion in 11 mmol/l glucose		38
Primary islets from humans			No change	No change	30
Primary islets from ZDF rats			Decrease	Increase	39
Type 2 diabetic humans	Decrease	Decrease	Decrease	Increase	4
db/db mice	Decrease	Increase^*	Increased intracellular insulin content of β-cells		35
db/db mice	Decrease	No change	Increased intracellular insulin content of β-cells		37
ob/ob mice	Decrease	Decrease		Increase	34
KK mice	Decrease	Decrease		Increase	34
ZDF rats	Decrease	Decrease	Decrease, increased insulin transcription	Increase	5,33,34,36,40

*

NS.