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TABLE 1

Clinical characteristics of the three study populations

CategorynAge (years)Duration of diabetes (years)A1C (%)Albumin excretion (μg/min)GFR (ml · min−1 · 1.73 mol/l−2)
ONPN cohort       
    Progressors 42.7 ± 10.8 26.5 ± 3.9 9.3 ± 1.7 90.5 ± 139.2 61 ± 36*§ 
    Nonprogressors 44.3 ± 11.4 33.5 ± 12. 8.1 ± 1.3 7.5 ± 3.5 136 ± 45§ 
NHS cohort       
    Upper quintile GBM width 22 18.7 ± 5.0 10.6 ± 2.9 9.2 ± 1.9 9.0 ± 13.2 128 ± 17 
    Lower quintile GBM width 22 26.3 ± 8.0 15.6 ± 4.8 8.2 ± 1.5 9.2 ± 9.1 130 ± 26 
Pima Indiana cohort       
    Upper quartile GBM width 11 41.1 ± 12.9 6.3 ± 5.5 9.4 ± 2.4 1620 ± 1807 116 ± 50 
    Lower quartile GBM width 11 43.1 ± 10.5 17.8 ± 5.4 10.8 ± 1.7 40 ± 60 132 ± 36 
CategorynAge (years)Duration of diabetes (years)A1C (%)Albumin excretion (μg/min)GFR (ml · min−1 · 1.73 mol/l−2)
ONPN cohort       
    Progressors 42.7 ± 10.8 26.5 ± 3.9 9.3 ± 1.7 90.5 ± 139.2 61 ± 36*§ 
    Nonprogressors 44.3 ± 11.4 33.5 ± 12. 8.1 ± 1.3 7.5 ± 3.5 136 ± 45§ 
NHS cohort       
    Upper quintile GBM width 22 18.7 ± 5.0 10.6 ± 2.9 9.2 ± 1.9 9.0 ± 13.2 128 ± 17 
    Lower quintile GBM width 22 26.3 ± 8.0 15.6 ± 4.8 8.2 ± 1.5 9.2 ± 9.1 130 ± 26 
Pima Indiana cohort       
    Upper quartile GBM width 11 41.1 ± 12.9 6.3 ± 5.5 9.4 ± 2.4 1620 ± 1807 116 ± 50 
    Lower quartile GBM width 11 43.1 ± 10.5 17.8 ± 5.4 10.8 ± 1.7 40 ± 60 132 ± 36 

Data are means ± SD.

*

P = 0.01,

P < 0.001,

P = 0.002,

§

creatinine clearance (ml/min),

mg/g creatinine.

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