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TABLE 1

Statistics on the day of killing for nondiabetic control rats, diabetic rats, diabetic rats treated with rosuvastatin, diabetic rats treated with simvastatin, and diabetic rats treated with rosuvastatin and mevalonate

ControlDiabetesDiabetes + rosuvastatinDiabetes + simvastatinDiabetes + rosuvastatin and mevalonate
Body weight (gm) 331.7 ± 13.4 190.7 ± 9.5* 236.6 ± 10.5* 212.1 ± 18.3* 210.7 ± 20.4* 
Water intake (ml/day) 26.7 ± 0.7 85.7 ± 2.8* 90.0 ± 5.2* 92.5 ± 4.5* 92.1 ± 8.6* 
Serum glucose (mg/dl) 195.5 ± 7.3 479.60.3 ± 25.5* 527.9 ± 17.5* 501.9 ± 34.9* 546.0 ± 33.0* 
Serum creatinine (mg/dl) 0.65 ± 0.07 0.48 ± 0.02* 0.36 ± 0.04* 0.47 ± 0.07* 0.40 ± 0.08* 
ControlDiabetesDiabetes + rosuvastatinDiabetes + simvastatinDiabetes + rosuvastatin and mevalonate
Body weight (gm) 331.7 ± 13.4 190.7 ± 9.5* 236.6 ± 10.5* 212.1 ± 18.3* 210.7 ± 20.4* 
Water intake (ml/day) 26.7 ± 0.7 85.7 ± 2.8* 90.0 ± 5.2* 92.5 ± 4.5* 92.1 ± 8.6* 
Serum glucose (mg/dl) 195.5 ± 7.3 479.60.3 ± 25.5* 527.9 ± 17.5* 501.9 ± 34.9* 546.0 ± 33.0* 
Serum creatinine (mg/dl) 0.65 ± 0.07 0.48 ± 0.02* 0.36 ± 0.04* 0.47 ± 0.07* 0.40 ± 0.08* 

Data are means ± SE; n = 10 in each group.

*

P < 0.01 compared with controls. As expected, all diabetic rat groups had significantly lower body weight and serum creatinine levels and significantly increased water consumption and serum glucose levels. These parameters were not significantly different among the various diabetic rat groups.

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