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TABLE 4

Volume of distribution (μl/g) of fluorescent dextrans with various molecular weights (250, 70, 40, and 20 kDa) in cardiac tissue of nondiabetic control rats, diabetic rats, diabetic rats treated with rosuvastatin, diabetic rats treated with simvastatin, and diabetic rats treated with rosuvastatin and mevalonate for 5 weeks

kDaControlDiabetesDiabetes + rosuvastatinDiabetes + simvastatinDiabetes + rosuvastatin and mevalonate
250 56.05 ± 4.27 37.82 ± 11.48 23.38 ± 6.96* 49.71 ± 4.30 36.12 ± 3.63* 
70 45.83 ± 5.63 59.59 ± 20.56 29.87 ± 9.65 59.49 ± 8.60 50.99 ± 9.10 
40 57.05 ± 7.66 93.60 ± 11.17* 39.95 ± 10.75 45.20 ± 10.10 36.50 ± 6.10 
20 24.05 ± 3.67 24.28 ± 8.28 40.10 ± 8.16 44.08 ± 5.60 45.20 ± 10.11 
kDaControlDiabetesDiabetes + rosuvastatinDiabetes + simvastatinDiabetes + rosuvastatin and mevalonate
250 56.05 ± 4.27 37.82 ± 11.48 23.38 ± 6.96* 49.71 ± 4.30 36.12 ± 3.63* 
70 45.83 ± 5.63 59.59 ± 20.56 29.87 ± 9.65 59.49 ± 8.60 50.99 ± 9.10 
40 57.05 ± 7.66 93.60 ± 11.17* 39.95 ± 10.75 45.20 ± 10.10 36.50 ± 6.10 
20 24.05 ± 3.67 24.28 ± 8.28 40.10 ± 8.16 44.08 ± 5.60 45.20 ± 10.11 

Data are means ± SE; n = 10 in each group.

*

P < 0.05 compared with nondiabetic control rats,

P < 0.05 compared with diabetic rats.

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