Skip to Main Content
TABLE 1

Main clinical characteristics of the patients with MODY5 and of those with no molecular alteration of TCF2

Molecular alteration of TCF2
P
YesNo
n 28 12  
Age at latest follow-up (years) 42.8 ± 13.2 (13–73) 55.3 ± 15.4 (21–71) 0.01 
Age at first manifestation (years) 24.2 ± 14.8 (1–58) 42.1 ± 18.2 (1–60) 0.004 
Diabetes    
    Age at diagnosis (years) 28.1 ± 13.1 (10–58) 46.3 ± 14.3 (17–61) 0.002 
    Symptoms at diagnosis (yes/no) 11/17 2/10 NS 
    BMI at diagnosis (kg/m223.8 ± 3.8 (15–32) 27.4 ± 3.1 (21.6–32.5) 0.004 
    HbA1c at last examination (%) 7.2 ± 1.2 (5.5–9.5) 7.2 ± 1.5 (5.3–10.8) NS 
    Insulin therapy (yes/no) 20/8 2/10 0.002 
Kidney disease    
    Age at diagnosis (years) 28.9 ± 16.9 (1–63) 47.8 ± 17.1 (1–66) 0.002 
    Presence of kidney cysts (yes/no) 21/7 10/2 NS 
    Other kidney morphological abnormalities (yes/no)* 14/14 1/11 0.01 
    Creatinine clearance at latest examination (ml/min per 1.73 m247.0 ± 26 (5.5–108) 52.7 ± 27.2 (23.9–96) NS 
    Systolic blood pressure (mmHg) 127 ± 17 (104–170) 139 ± 12 (117–160) 0.01 
    Diastolic blood pressure (mmHg) 75 ± 7 (60–90) 77 ± 9 (64–95) NS 
Liver disease    
    Liver tests abnormalities (yes/no) 23/4 4/6 0.01 
First-degree family history    
    Diabetes (yes/no) 12/16 10/2 0.03 
    Renal disease (yes/no) 11/17 5/7 NS 
Molecular alteration of TCF2
P
YesNo
n 28 12  
Age at latest follow-up (years) 42.8 ± 13.2 (13–73) 55.3 ± 15.4 (21–71) 0.01 
Age at first manifestation (years) 24.2 ± 14.8 (1–58) 42.1 ± 18.2 (1–60) 0.004 
Diabetes    
    Age at diagnosis (years) 28.1 ± 13.1 (10–58) 46.3 ± 14.3 (17–61) 0.002 
    Symptoms at diagnosis (yes/no) 11/17 2/10 NS 
    BMI at diagnosis (kg/m223.8 ± 3.8 (15–32) 27.4 ± 3.1 (21.6–32.5) 0.004 
    HbA1c at last examination (%) 7.2 ± 1.2 (5.5–9.5) 7.2 ± 1.5 (5.3–10.8) NS 
    Insulin therapy (yes/no) 20/8 2/10 0.002 
Kidney disease    
    Age at diagnosis (years) 28.9 ± 16.9 (1–63) 47.8 ± 17.1 (1–66) 0.002 
    Presence of kidney cysts (yes/no) 21/7 10/2 NS 
    Other kidney morphological abnormalities (yes/no)* 14/14 1/11 0.01 
    Creatinine clearance at latest examination (ml/min per 1.73 m247.0 ± 26 (5.5–108) 52.7 ± 27.2 (23.9–96) NS 
    Systolic blood pressure (mmHg) 127 ± 17 (104–170) 139 ± 12 (117–160) 0.01 
    Diastolic blood pressure (mmHg) 75 ± 7 (60–90) 77 ± 9 (64–95) NS 
Liver disease    
    Liver tests abnormalities (yes/no) 23/4 4/6 0.01 
First-degree family history    
    Diabetes (yes/no) 12/16 10/2 0.03 
    Renal disease (yes/no) 11/17 5/7 NS 

Data are means ± SD (range). Comparisons between groups were performed using Mann-Whitney test or Fisher’s exact test where appropriate. HbA1c normal values, 4–6%.

*

Renal agenesis, renal atrophy, and pelvicaliceal abnormalities.

Close Modal

or Create an Account

Close Modal
Close Modal