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TABLE 1

Body weight and retroperitoneal fat pad weight for WT and KO mice with ad libitum or calorie-restricted feeding

WT
KO
Ad libitumCalorie restrictionAd libitumCalorie restriction
Males     
    Initial weight (g) 23.6 ± 0.7* 24.6 ± 0.5 21.4 ± 0.6 22.5 ± 0.6 
    Final weight (g) 25.4 ± 0.8* 17.7 ± 0.3* 23.3 ± 0.5* 17.3 ± 0.5 
    Fat pad (g) 0.171 ± 0.024* 0.021 ± 0.004 0.073 ± 0.009* 0.019 ± 0.002 
Females     
    Initial weight (g) 19.6 ± 0.5 19.8 ± 0.5 17.8 ± 0.6 17.8 ± 0.4 
    Final weight (g) 20.7 ± 0.4* 16.1 ± 0.5 19.9 ± 0.6* 14.8 ± 0.5 
    Fat pad (g) 0.063 ± 0.010* 0.040 ± 0.007 0.038 ± 0.009 0.022 ± 0.003 
WT
KO
Ad libitumCalorie restrictionAd libitumCalorie restriction
Males     
    Initial weight (g) 23.6 ± 0.7* 24.6 ± 0.5 21.4 ± 0.6 22.5 ± 0.6 
    Final weight (g) 25.4 ± 0.8* 17.7 ± 0.3* 23.3 ± 0.5* 17.3 ± 0.5 
    Fat pad (g) 0.171 ± 0.024* 0.021 ± 0.004 0.073 ± 0.009* 0.019 ± 0.002 
Females     
    Initial weight (g) 19.6 ± 0.5 19.8 ± 0.5 17.8 ± 0.6 17.8 ± 0.4 
    Final weight (g) 20.7 ± 0.4* 16.1 ± 0.5 19.9 ± 0.6* 14.8 ± 0.5 
    Fat pad (g) 0.063 ± 0.010* 0.040 ± 0.007 0.038 ± 0.009 0.022 ± 0.003 

Data are means ± SE. Initial (day 1 of calorie reduction) and final (day 20 of calorie reduction) body weight was measured (n = 7–10). Retroperitoneal fat pad was weighed after day 20 (n = 7–9). For each sex, data analyzed by two-way ANOVA for diet and genotype. Tukey post hoc analysis:

*

P < 0.05 AL > CR within genotype;

P < 0.05 WT > KO within diet.

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