Serum insulin and glucose for WT or KO mice after ad libitum or calorie-restricted diet
| . | WT . | . | KO . | . | ||
|---|---|---|---|---|---|---|
| . | Ad libitum . | Calorie restriction . | Ad libitum . | Calorie restriction . | ||
| Males | ||||||
| Insulin (ng/ml) | 1.0 ± 0.2* | 0.4 ± 0.1* | 11.6 ± 13.3† | 1.3 ± 0.2 | ||
| Glucose (mmol) | 8.8 ± 0.4† | 6.2 ± 0.5* | 7.8 ± 0.6 | 8.6 ± 0.4 | ||
| Females | ||||||
| Insulin (ng/ml) | 0.5 ± 0.1 | 0.5 ± 0.1* | 1.2 ± 0.4† | 3.5 ± 0.8 | ||
| Glucose (mmol) | 8.2 ± 0.4 | 8.1 ± 0.5 | 8.0 ± 0.9 | 8.3 ± 1.2 | ||
| . | WT . | . | KO . | . | ||
|---|---|---|---|---|---|---|
| . | Ad libitum . | Calorie restriction . | Ad libitum . | Calorie restriction . | ||
| Males | ||||||
| Insulin (ng/ml) | 1.0 ± 0.2* | 0.4 ± 0.1* | 11.6 ± 13.3† | 1.3 ± 0.2 | ||
| Glucose (mmol) | 8.8 ± 0.4† | 6.2 ± 0.5* | 7.8 ± 0.6 | 8.6 ± 0.4 | ||
| Females | ||||||
| Insulin (ng/ml) | 0.5 ± 0.1 | 0.5 ± 0.1* | 1.2 ± 0.4† | 3.5 ± 0.8 | ||
| Glucose (mmol) | 8.2 ± 0.4 | 8.1 ± 0.5 | 8.0 ± 0.9 | 8.3 ± 1.2 | ||
Data are means ± SE (n = 4–5). Data were log transformed to normalize distribution and analyzed by two-way ANOVA for diet and genotype in each sex. Untransformed data are shown. Tukey post hoc analysis:
P < 0.05 WT < KO within diet;
P < 0.05 AL vs. CR within genotype.