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TABLE 2

Serum insulin and glucose for WT or KO mice after ad libitum or calorie-restricted diet

WT
KO
Ad libitumCalorie restrictionAd libitumCalorie restriction
Males     
    Insulin (ng/ml) 1.0 ± 0.2* 0.4 ± 0.1* 11.6 ± 13.3 1.3 ± 0.2 
    Glucose (mmol) 8.8 ± 0.4 6.2 ± 0.5* 7.8 ± 0.6 8.6 ± 0.4 
Females     
    Insulin (ng/ml) 0.5 ± 0.1 0.5 ± 0.1* 1.2 ± 0.4 3.5 ± 0.8 
    Glucose (mmol) 8.2 ± 0.4 8.1 ± 0.5 8.0 ± 0.9 8.3 ± 1.2 
WT
KO
Ad libitumCalorie restrictionAd libitumCalorie restriction
Males     
    Insulin (ng/ml) 1.0 ± 0.2* 0.4 ± 0.1* 11.6 ± 13.3 1.3 ± 0.2 
    Glucose (mmol) 8.8 ± 0.4 6.2 ± 0.5* 7.8 ± 0.6 8.6 ± 0.4 
Females     
    Insulin (ng/ml) 0.5 ± 0.1 0.5 ± 0.1* 1.2 ± 0.4 3.5 ± 0.8 
    Glucose (mmol) 8.2 ± 0.4 8.1 ± 0.5 8.0 ± 0.9 8.3 ± 1.2 

Data are means ± SE (n = 4–5). Data were log transformed to normalize distribution and analyzed by two-way ANOVA for diet and genotype in each sex. Untransformed data are shown. Tukey post hoc analysis:

*

P < 0.05 WT < KO within diet;

P < 0.05 AL vs. CR within genotype.

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