American Diabetes Association

TABLE 3

Insulin-stimulated 2DG (2DG uptake with insulin minus basal 2DG uptake)

	WT			KO
		Ad libitum	Calorie restriction	Ad libitum	Calorie restriction
Males
EDL (μmol · g⁻¹ · 20 min⁻¹)	0.137 ± 0.04	0.309 ± 0.06^*^†	0.054 ± 0.05	−0.008 ± 0.03
Soleus (μmol · g⁻¹ · 20 min⁻¹)	0.197 ± 0.04	0.448 ± 0.07^*^†	0.036 ± 0.05	0.269 ± 0.07^*
Females
EDL (μmol · g⁻¹ · 20 min⁻¹)	0.174 ± 0.04	0.416 ± 0.09^*^†	0.027 ± 0.03	0.148 ± 0.04
Soleus (μmol · g⁻¹ · 20 min⁻¹)	0.340 ± 0.04	0.582 ± 0.04^*^†	0.147 ± 0.04	0.192 ± 0.05

	WT			KO
		Ad libitum	Calorie restriction	Ad libitum	Calorie restriction
Males
EDL (μmol · g⁻¹ · 20 min⁻¹)	0.137 ± 0.04	0.309 ± 0.06^*^†	0.054 ± 0.05	−0.008 ± 0.03
Soleus (μmol · g⁻¹ · 20 min⁻¹)	0.197 ± 0.04	0.448 ± 0.07^*^†	0.036 ± 0.05	0.269 ± 0.07^*
Females
EDL (μmol · g⁻¹ · 20 min⁻¹)	0.174 ± 0.04	0.416 ± 0.09^*^†	0.027 ± 0.03	0.148 ± 0.04
Soleus (μmol · g⁻¹ · 20 min⁻¹)	0.340 ± 0.04	0.582 ± 0.04^*^†	0.147 ± 0.04	0.192 ± 0.05

Data are means ± SE (n = 9–15). Values represent the effect of insulin on 2DG uptake above basal. For each sex, data are analyzed by two-way ANOVA for diet and genotype. Tukey post hoc analysis:

P < 0.05 AL < CR with same genotype;

†

P < 0.05 WT > KO within diet.

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