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TABLE 3

Insulin-stimulated 2DG (2DG uptake with insulin minus basal 2DG uptake)

WT
KO
Ad libitumCalorie restrictionAd libitumCalorie restriction
Males     
    EDL (μmol · g−1 · 20 min−10.137 ± 0.04 0.309 ± 0.06* 0.054 ± 0.05 −0.008 ± 0.03 
    Soleus (μmol · g−1 · 20 min−10.197 ± 0.04 0.448 ± 0.07* 0.036 ± 0.05 0.269 ± 0.07* 
Females     
    EDL (μmol · g−1 · 20 min−10.174 ± 0.04 0.416 ± 0.09* 0.027 ± 0.03 0.148 ± 0.04 
    Soleus (μmol · g−1 · 20 min−10.340 ± 0.04 0.582 ± 0.04* 0.147 ± 0.04 0.192 ± 0.05 
WT
KO
Ad libitumCalorie restrictionAd libitumCalorie restriction
Males     
    EDL (μmol · g−1 · 20 min−10.137 ± 0.04 0.309 ± 0.06* 0.054 ± 0.05 −0.008 ± 0.03 
    Soleus (μmol · g−1 · 20 min−10.197 ± 0.04 0.448 ± 0.07* 0.036 ± 0.05 0.269 ± 0.07* 
Females     
    EDL (μmol · g−1 · 20 min−10.174 ± 0.04 0.416 ± 0.09* 0.027 ± 0.03 0.148 ± 0.04 
    Soleus (μmol · g−1 · 20 min−10.340 ± 0.04 0.582 ± 0.04* 0.147 ± 0.04 0.192 ± 0.05 

Data are means ± SE (n = 9–15). Values represent the effect of insulin on 2DG uptake above basal. For each sex, data are analyzed by two-way ANOVA for diet and genotype. Tukey post hoc analysis:

*

P < 0.05 AL < CR with same genotype;

P < 0.05 WT > KO within diet.

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