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TABLE 1

Studies of the IL6−174G>C SNP in type 1 diabetes

Population (ref. no.)DesignStudy cohortSexAssociated alleleP
UK (15) C-C 257 type 1 diabetic/120 control M/F IL6-174G 0.0001 
UK (15) TDT 53 trios M/F None NS 
DK (8) TDT 253 type 1 diabetic families* M/F IL6-174C 0.04 
 TDT 165 trios IL6-174C 0.0002 
 TDT 168 trios None NS 
NL (16) TDT 206 trios M/F None NA 
Population (ref. no.)DesignStudy cohortSexAssociated alleleP
UK (15) C-C 257 type 1 diabetic/120 control M/F IL6-174G 0.0001 
UK (15) TDT 53 trios M/F None NS 
DK (8) TDT 253 type 1 diabetic families* M/F IL6-174C 0.04 
 TDT 165 trios IL6-174C 0.0002 
 TDT 168 trios None NS 
NL (16) TDT 206 trios M/F None NA 

C-C, case-control study; TDT, transmission disequilibrium testing, a family-based design.

*

150 type 1 diabetic sibpair families and 103 type 1 diabetic trio families.

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