Skip to Main Content
TABLE 2

Genetic studies of IL6 and IL6R in type 2 diabetes and insulin resistance

AssociationPopulation (ref. no.)GeneSNPAssociated allele/ genotypeCommentPower*
Type 2 diabetes Native Americans (22) IL6 −174G>C G/GG Pimas are GG heterozygous 
Type 2 diabetes Spanish Caucasians (22) IL6 −174G>C G/GG  
Type 2 diabetes U.K. Caucasians (23) IL6 −174G>C Only males included 
Type 2 diabetes Germans (19) IL6 −174G>C Association only significant in males and lean subjects 
Type 2 diabetes  IL6 −597G>A  
Type 2 diabetes Danes (24) IL6 −174G>C None  
Type 2 diabetes  IL6 −572G>C GG SNP not in Hardy-Weinberg equilibrium in control group 
Type 2 diabetes  IL6 −597G>A None  
Type 2 diabetes  IL6 Haplotype GCG AGC/GCG Haplotype of −597, −572, and −174 SNPs, trend (P = 0.06) of association for GCG 
Conversion from impaired glucose tolerance to type 2 diabetes Finns (25) IL6 −174G>C CC Only in combination with TNFA-308 A allele carriers 
Prospective risk of developing type 2 diabetes Germans (26) IL6 −174G>C CC In individuals with BMI >28 kg/m2 
Type 2 diabetes Pimas (27) IL6R rs8192284 None  
Type 2 diabetes Utah Caucasians (11) IL6R rs8192284 Asp358 Trend (P = 0.053) 
Type 2 diabetes African Americans (11) IL6R rs8192284 None  
Type 2 diabetes Danes (12) IL6R rs8192284 Asp358  
Type 2 diabetes African Americans (11) IL6R rs2229238 385Ile   
High insulin sensitivity Catalonians (28) IL6 −174G>C CC  
Low insulin sensitivity Finns (29) IL6 −174G>C CC  
Low insulin sensitivity Germans (19) IL6 −174G>C None  
Low insulin sensitivity Danes (24) IL6 −174G>C  
AssociationPopulation (ref. no.)GeneSNPAssociated allele/ genotypeCommentPower*
Type 2 diabetes Native Americans (22) IL6 −174G>C G/GG Pimas are GG heterozygous 
Type 2 diabetes Spanish Caucasians (22) IL6 −174G>C G/GG  
Type 2 diabetes U.K. Caucasians (23) IL6 −174G>C Only males included 
Type 2 diabetes Germans (19) IL6 −174G>C Association only significant in males and lean subjects 
Type 2 diabetes  IL6 −597G>A  
Type 2 diabetes Danes (24) IL6 −174G>C None  
Type 2 diabetes  IL6 −572G>C GG SNP not in Hardy-Weinberg equilibrium in control group 
Type 2 diabetes  IL6 −597G>A None  
Type 2 diabetes  IL6 Haplotype GCG AGC/GCG Haplotype of −597, −572, and −174 SNPs, trend (P = 0.06) of association for GCG 
Conversion from impaired glucose tolerance to type 2 diabetes Finns (25) IL6 −174G>C CC Only in combination with TNFA-308 A allele carriers 
Prospective risk of developing type 2 diabetes Germans (26) IL6 −174G>C CC In individuals with BMI >28 kg/m2 
Type 2 diabetes Pimas (27) IL6R rs8192284 None  
Type 2 diabetes Utah Caucasians (11) IL6R rs8192284 Asp358 Trend (P = 0.053) 
Type 2 diabetes African Americans (11) IL6R rs8192284 None  
Type 2 diabetes Danes (12) IL6R rs8192284 Asp358  
Type 2 diabetes African Americans (11) IL6R rs2229238 385Ile   
High insulin sensitivity Catalonians (28) IL6 −174G>C CC  
Low insulin sensitivity Finns (29) IL6 −174G>C CC  
Low insulin sensitivity Germans (19) IL6 −174G>C None  
Low insulin sensitivity Danes (24) IL6 −174G>C  
*

The reports were ranked based on the number of investigated individuals and thus the power of the study: 1 = low, 2 = intermediate, or 3 = high power. Only studies evaluating insulin resistance using minimal model measures or the euglycemic-hyperinsulinemic clamp were included, since studies using less precise determinations of insulin resistance may be flawed. Studies investigating obesity alone contain no comments. Not all genetic variants investigated are commented on if considered noninformative in the context or no association was established.

Close Modal

or Create an Account

Close Modal
Close Modal