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TABLE 4

In vitro IL-6 effects on islet insulin production

Ref. no.SpeciesIL-6 concentrationTime ofincubation (h)Medium insulin accumulationInsulin release (glucose concentration [mmol/l])
32  Rat 500–2,000 ng/ml 48 ↑ → (1.67), ↓ (16.7) 
  5,000 ng/ml 48 → → (1.67), ↓ (16.7) 
31  Rat 0.1 pmol/l to 1.0 nmol/l 0.5 NA → (8) 
  0.1 pmol/l 24 NA → (2), → (20) 
  10 pmol/l 24 NA → (2), ↓ (20) 
  1 nmol/l 24 NA ↑ (2), ↓ (20) 
34  Rat 10 nmol/l → ↓ (16.7) 
47  Mouse 500–5,000 units/ml 24–72 NA ↑ (NA) 
37  Mouse 400 ng/ml 24 NA → (2), → (20) 
33  Human 125 ng/ml 48 → → (1.67), → (16.7) 
Ref. no.SpeciesIL-6 concentrationTime ofincubation (h)Medium insulin accumulationInsulin release (glucose concentration [mmol/l])
32  Rat 500–2,000 ng/ml 48 ↑ → (1.67), ↓ (16.7) 
  5,000 ng/ml 48 → → (1.67), ↓ (16.7) 
31  Rat 0.1 pmol/l to 1.0 nmol/l 0.5 NA → (8) 
  0.1 pmol/l 24 NA → (2), → (20) 
  10 pmol/l 24 NA → (2), ↓ (20) 
  1 nmol/l 24 NA ↑ (2), ↓ (20) 
34  Rat 10 nmol/l → ↓ (16.7) 
47  Mouse 500–5,000 units/ml 24–72 NA ↑ (NA) 
37  Mouse 400 ng/ml 24 NA → (2), → (20) 
33  Human 125 ng/ml 48 → → (1.67), → (16.7) 

NA, not available. →, unchanged; ↑, increased; ↓, decreased.

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