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TABLE 1

Allele frequencies for the H324Q (C→A) SNP in LARS2 in four different cohorts

CohortNGT
Type 2 diabetes
POdds ratio (95% CI)
CACA
Hoorn study 659 13 (0.019) 404 18 (0.043) 0.04 2.26 (1.10–4.66) 
ERGO (Rotterdam) study 889 25 (0.027) 879 35 (0.038) 0.19 1.42 (0.84–2.39) 
DK1, Steno case-control study 1,005 23 (0.022) 1,373 39 (0.028) 0.44 1.24 (0.74–2.10) 
DK2, Inter99 case-control study 8,746 256 (0.028) 1,259 49 (0.037) 0.08 1.33 (0.97–1.82) 
Common odds ratio — — — — 0.004 1.40 (1.12–1.76) 
CohortNGT
Type 2 diabetes
POdds ratio (95% CI)
CACA
Hoorn study 659 13 (0.019) 404 18 (0.043) 0.04 2.26 (1.10–4.66) 
ERGO (Rotterdam) study 889 25 (0.027) 879 35 (0.038) 0.19 1.42 (0.84–2.39) 
DK1, Steno case-control study 1,005 23 (0.022) 1,373 39 (0.028) 0.44 1.24 (0.74–2.10) 
DK2, Inter99 case-control study 8,746 256 (0.028) 1,259 49 (0.037) 0.08 1.33 (0.97–1.82) 
Common odds ratio — — — — 0.004 1.40 (1.12–1.76) 

Data are total number (fraction of total number), unless otherwise indicated. P values were calculated using Fisher exact tests.

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