Skip to Main Content
TABLE 2

Clinical characteristics of NGT subjects in the different study populations in relation to LARS2 His324Gln polymorphism

Hoorn study
ERGO study
DK2, Inter99 study
HHHQ + QQHHHQ + QQHHHQ + QQ
n 323 13 432 25 4,248 253 
Age (years) 60 ± 7 61 ± 5 64 ± 5 66 ± 5* 45.2 ± 7.8 44.6 ± 7.7 
Sex (male/female) 128/195 4/9 238/194 11/14 1,964/2,284 130/123 
BMI (kg/m226.1 ± 3.0 25.7 ± 2.6 25.9 ± 3.2 25.2 ± 4.1 25.5 ± 4.1 25.3 ± 3.7 
HbA1c (%) 5.5 ± 0.4 5.2 ± 0.4 5.8 ± 0.5 5.8 ± 0.7 5.8 ± 0.4 5.7 ± 0.4 
Fasting glucose (mmol/l) 5.4 ± 0.5 5.1 ± 0.4 5.4 ± 0.4 5.4 ± 0.4 5.3 ± 0.4 5.3 ± 0.4 
2-h glucose (mmol/l) 5.2 ± 1.3 5.1 ± 1.3 5.3 ± 1.1 5.4 ± 1.1 5.5 ± 1.1 5.5 ± 1.2 
Fasting insulin (pmol/l) 79 ± 36 71 ± 16 69 ± 34 69 ± 32 37 ± 23 39 ± 24 
2-h insulin (pmol/l) NA NA 60 ± 50 77 ± 56 168 ± 131 164 ± 124 
HOMA-IR 19.0 ± 9.8 16.2 ± 3.7 17.0 ± 8.8 16.9 ± 9.0 8.9 ± 5.7 9.2 ± 5.7 
Cholesterol (mmol/l) 6.6 ± 1.1 6.4 ± 1.1 6.6 ± 1.0 6.3 ± 1.2 5.4 ± 1.0 5.3 ± 1.0 
HDL (mmol/l) 1.33 ± 0.34 1.50 ± 0.65 1.34 ± 0.33 1.31 ± 0.37 1.46 ± 0.40 1.40 ± 0.37 
Triglycerides (mmol/l) 1.41 ± 0.67 1.38 ± 0.58 1.48 ± 0.62 1.70 ± 1.03 1.19 ± 0.95 1.14 ± 0.79 
Free fatty acids (mmol/l) 0.58 ± 0.21 0.55 ± 0.17 0.29 ± 0.09 0.34 ± 0.12* NA NA 
Hoorn study
ERGO study
DK2, Inter99 study
HHHQ + QQHHHQ + QQHHHQ + QQ
n 323 13 432 25 4,248 253 
Age (years) 60 ± 7 61 ± 5 64 ± 5 66 ± 5* 45.2 ± 7.8 44.6 ± 7.7 
Sex (male/female) 128/195 4/9 238/194 11/14 1,964/2,284 130/123 
BMI (kg/m226.1 ± 3.0 25.7 ± 2.6 25.9 ± 3.2 25.2 ± 4.1 25.5 ± 4.1 25.3 ± 3.7 
HbA1c (%) 5.5 ± 0.4 5.2 ± 0.4 5.8 ± 0.5 5.8 ± 0.7 5.8 ± 0.4 5.7 ± 0.4 
Fasting glucose (mmol/l) 5.4 ± 0.5 5.1 ± 0.4 5.4 ± 0.4 5.4 ± 0.4 5.3 ± 0.4 5.3 ± 0.4 
2-h glucose (mmol/l) 5.2 ± 1.3 5.1 ± 1.3 5.3 ± 1.1 5.4 ± 1.1 5.5 ± 1.1 5.5 ± 1.2 
Fasting insulin (pmol/l) 79 ± 36 71 ± 16 69 ± 34 69 ± 32 37 ± 23 39 ± 24 
2-h insulin (pmol/l) NA NA 60 ± 50 77 ± 56 168 ± 131 164 ± 124 
HOMA-IR 19.0 ± 9.8 16.2 ± 3.7 17.0 ± 8.8 16.9 ± 9.0 8.9 ± 5.7 9.2 ± 5.7 
Cholesterol (mmol/l) 6.6 ± 1.1 6.4 ± 1.1 6.6 ± 1.0 6.3 ± 1.2 5.4 ± 1.0 5.3 ± 1.0 
HDL (mmol/l) 1.33 ± 0.34 1.50 ± 0.65 1.34 ± 0.33 1.31 ± 0.37 1.46 ± 0.40 1.40 ± 0.37 
Triglycerides (mmol/l) 1.41 ± 0.67 1.38 ± 0.58 1.48 ± 0.62 1.70 ± 1.03 1.19 ± 0.95 1.14 ± 0.79 
Free fatty acids (mmol/l) 0.58 ± 0.21 0.55 ± 0.17 0.29 ± 0.09 0.34 ± 0.12* NA NA 

Data are means ± SD. Three QQ homozygotes were detected in the DK2 cohort. P values were obtained after general linear regression (SPSS), with age and BMI as covariates and sex and genotype as fixed factors.

*

P ≤ 0.01,

P ≤ 0.05. HOMA-IR, homeostasis model assessment of insulin resistance.

Close Modal

or Create an Account

Close Modal
Close Modal