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TABLE 3

Frequency and severity of collagen-induced arthritis in LEW.1WR1 rats

TrialTreatmentnn (%) with arthritisMedian (range) latency to arthritis onset (days)Mean (±SD) maximal severity score
Collagen + IFA 24 20 (83)* 10 (10–12) 2.8 ± 0.6 
 IFA alone 0 (0) — 
Collagen + IFA 19 22 (86)* 14 (12–14) 3.0 ± 0.0 
 IFA alone 0 (0) — 
TrialTreatmentnn (%) with arthritisMedian (range) latency to arthritis onset (days)Mean (±SD) maximal severity score
Collagen + IFA 24 20 (83)* 10 (10–12) 2.8 ± 0.6 
 IFA alone 0 (0) — 
Collagen + IFA 19 22 (86)* 14 (12–14) 3.0 ± 0.0 
 IFA alone 0 (0) — 

LEW.1WR1 rats 32–48 days of age of either sex were randomized and injected with either type II collagen emulsified in IFA or IFA alone as described in research design and methods. Animals in trial 1 received a single injection; those in trial 2 received two injections separated by 8 days. Arthritis severity was scored on a scale of 0–3 as described in research design and methods. Time to onset was defined as the first of 2 consecutive days on which grade 1 or higher swelling was observed.

*

P < 0.001 vs. IFA alone group (Fisher exact statistic).

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