TABLE 1

Phenotyping of mice

129 LFD129 HFDB6 LFDB6 HFDSignificance
Weight (g)      
    0 weeks 24.8 ± 1.0 24.6 ± 1.7 23.5 ± 1.7 22.8 ± 1.6 * 
    18 weeks 30.9 ± 2.5 39.2 ± 4.3 41.5 ± 4.1 46.4 ± 3.2 **,†† 
Liver weight (mg)/body weight (g) 32 ± 5 34 ± 2 39 ± 4 69 ± 15 **,††,‡‡ 
Serum glucose (mg/dl)      
    Fasting 52 ± 10.6 62 ± 7.6 115 ± 23 117 ± 17 ** 
    Glucose tolerance test 92 ± 8.7 190 ± 24 240 ± 59 239 ± 77 **,, 
Insulin (ng/ml) 1.3 ± 0.6 3.6 ± 1.2 24.8 ± 35 32.7 ± 35 **, 
Leptin (ng/ml) 5.0 ± 1.5 47 ± 17 72 ± 23 82 ± 21 **,††,‡‡ 
129 LFD129 HFDB6 LFDB6 HFDSignificance
Weight (g)      
    0 weeks 24.8 ± 1.0 24.6 ± 1.7 23.5 ± 1.7 22.8 ± 1.6 * 
    18 weeks 30.9 ± 2.5 39.2 ± 4.3 41.5 ± 4.1 46.4 ± 3.2 **,†† 
Liver weight (mg)/body weight (g) 32 ± 5 34 ± 2 39 ± 4 69 ± 15 **,††,‡‡ 
Serum glucose (mg/dl)      
    Fasting 52 ± 10.6 62 ± 7.6 115 ± 23 117 ± 17 ** 
    Glucose tolerance test 92 ± 8.7 190 ± 24 240 ± 59 239 ± 77 **,, 
Insulin (ng/ml) 1.3 ± 0.6 3.6 ± 1.2 24.8 ± 35 32.7 ± 35 **, 
Leptin (ng/ml) 5.0 ± 1.5 47 ± 17 72 ± 23 82 ± 21 **,††,‡‡ 

Data are means ± SD for four to eight mice. Male mice were placed on an LFD or HFD for 18 weeks, after which weight, liver weight, glucose, insulin, and leptin were measured. Blood glucose was measured after an overnight fast, both before (fasting) and 2 h after a 2-g/kg bolus of glucose i.p. (glucose tolerance test). Significance is indicated in the last column, where

*

P ≤ 0.02 for strain effect,

P ≤ 0.02 for diet effect, and

P ≤ 0.02 for their interaction. Double symbols indicate P < 0.002.

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