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TABLE 2

Physiological and metabolic parameters of 35-week-old study groups

Genotype
Male wild typeFemale wild typeAR−/y
Mice (n10 
Body weight (g) 33.15 ± 1.2 25.81 ± 0.44 39.06 ± 2.7* 
Gonadal fat/body (%) 2.21 ± 0.14 0.34 ± 0.08 3.29 ± 0.23* 
Serum total triglycerides (mmol/l) 0.30 ± 0.04 0.32 ± 0.08 0.67 ± 0.1 
Serum nonesterified fatty acids (mEq/l) 0.25 ± 0.02 0.25 ± 0.02 0.71 ± 0.04 
Serum cholesterol (mmol/l) 2.28 ± 0.05 2.28 ± 0.06 2.44 ± 0.05 
Fasting blood glucose (mmol/l) 6.46 ± 0.31 6.41 ± 0.27 7.94 ± 0.38* 
Fed blood glucose (mmol/l) 14.03 ± 0.54 14.93 ± 0.29 19.75 ± 0.78 
Fasting serum insulin (ng/ml) 0.55 ± 0.13 0.53 ± 0.33 0.88 ± 0.33* 
Fed serum insulin (ng/ml) 0.92 ± 0.17 1.12 ± 0.14 1.54 ± 0.16* 
Genotype
Male wild typeFemale wild typeAR−/y
Mice (n10 
Body weight (g) 33.15 ± 1.2 25.81 ± 0.44 39.06 ± 2.7* 
Gonadal fat/body (%) 2.21 ± 0.14 0.34 ± 0.08 3.29 ± 0.23* 
Serum total triglycerides (mmol/l) 0.30 ± 0.04 0.32 ± 0.08 0.67 ± 0.1 
Serum nonesterified fatty acids (mEq/l) 0.25 ± 0.02 0.25 ± 0.02 0.71 ± 0.04 
Serum cholesterol (mmol/l) 2.28 ± 0.05 2.28 ± 0.06 2.44 ± 0.05 
Fasting blood glucose (mmol/l) 6.46 ± 0.31 6.41 ± 0.27 7.94 ± 0.38* 
Fed blood glucose (mmol/l) 14.03 ± 0.54 14.93 ± 0.29 19.75 ± 0.78 
Fasting serum insulin (ng/ml) 0.55 ± 0.13 0.53 ± 0.33 0.88 ± 0.33* 
Fed serum insulin (ng/ml) 0.92 ± 0.17 1.12 ± 0.14 1.54 ± 0.16* 

Data are the means ± SE. After a 14-h fast, animals were killed.

*

P < 0.05,

P < 0.01, and

P < 0.001, AR vs. male wild type.

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