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TABLE 1

Physiological and plasma parameters in mice fed a control diet or isocaloric high-fat diets containing 27% safflower oil or 27, 14.5, or 8% fish oil for 15 days

CONT27% SAFF27% FISH14.5% FISH8% FISH
Physiologic parameters      
    Body wt initial (g) 22.8 ± 0.7 22.7 ± 0.8 22.9 ± 0.6 22.5 ± 0.3 22.6 ± 0.3 
    Body wt gain (g until day 15) 2.9 ± 0.4 6.2 ± 0.4* 5.1 ± 0.7 6.9 ± 0.5* 6.6 ± 0.2* 
    Body fat content initial (% body wt) 11.8 ± 0.4 11.0 ± 0.7 11.3 ± 0.6 11.2 ± 0.6 11.5 ± 0.9 
    Body fat gain (% body wt until day 15) 10.8 ± 0.9 18.1 ± 2.2 17.0 ± 2.2 18.1 ± 1.3 16.2 ± 1.2 
    Epididymal fat (% body wt) 3.0 ± 0.3 4.1 ± 0.0* 4.0 ± 0.2 4.0 ± 0.1 4.1 ± 0.3 
Plasma metabolites      
    Glucose (mg/dl) 178 ± 9 171 ± 5 171 ± 4 171 ± 12 176 ± 6 
    Total cholesterol (mg/dl) 133 ± 7 152 ± 4 117 ± 2 140 ± 3§ 134 ± 5§ 
    HDL cholesterol (mg/dl) 134 ± 6 148 ± 5 110 ± 1 136 ± 3 142 ± 2 
    Triacylglycerol (mmol/l) 80 ± 3 81 ± 4 50 ± 4 62 ± 4§ 77 ± 7 
    Nonesterified fatty acid (meq/l) 1.22 ± 0.15 1.27 ± 0.03 0.87 ± 0.05 0.97 ± 0.06 1.14 ± 0.05 
    β-Hydroxybutyrate (mmol/l) 0.13 ± 0.02 0.18 ± 0.02 0.23 ± 0.02 0.20 ± 0.03 0.17 ± 0.02 
Plasma hormones and adipocyte cytokines      
    Insulin (μU/ml) 31 ± 4 31 ± 4 23 ± 2 27 ± 2 31 ± 4 
    Corticosterone (ng/ml) 176 ± 23 147 ± 19 153 ± 30 180 ± 24 162 ± 31 
    Resistin (ng/ml) 4.8 ± 0.3 4.3 ± 0.4 4.7 ± 0.3 4.5 ± 0.4 4.3 ± 0.3 
    Leptin (ng/ml) 17 ± 3 42 ± 4 26 ± 5§ 46.7 ± 3.1 39 ± 3 
CONT27% SAFF27% FISH14.5% FISH8% FISH
Physiologic parameters      
    Body wt initial (g) 22.8 ± 0.7 22.7 ± 0.8 22.9 ± 0.6 22.5 ± 0.3 22.6 ± 0.3 
    Body wt gain (g until day 15) 2.9 ± 0.4 6.2 ± 0.4* 5.1 ± 0.7 6.9 ± 0.5* 6.6 ± 0.2* 
    Body fat content initial (% body wt) 11.8 ± 0.4 11.0 ± 0.7 11.3 ± 0.6 11.2 ± 0.6 11.5 ± 0.9 
    Body fat gain (% body wt until day 15) 10.8 ± 0.9 18.1 ± 2.2 17.0 ± 2.2 18.1 ± 1.3 16.2 ± 1.2 
    Epididymal fat (% body wt) 3.0 ± 0.3 4.1 ± 0.0* 4.0 ± 0.2 4.0 ± 0.1 4.1 ± 0.3 
Plasma metabolites      
    Glucose (mg/dl) 178 ± 9 171 ± 5 171 ± 4 171 ± 12 176 ± 6 
    Total cholesterol (mg/dl) 133 ± 7 152 ± 4 117 ± 2 140 ± 3§ 134 ± 5§ 
    HDL cholesterol (mg/dl) 134 ± 6 148 ± 5 110 ± 1 136 ± 3 142 ± 2 
    Triacylglycerol (mmol/l) 80 ± 3 81 ± 4 50 ± 4 62 ± 4§ 77 ± 7 
    Nonesterified fatty acid (meq/l) 1.22 ± 0.15 1.27 ± 0.03 0.87 ± 0.05 0.97 ± 0.06 1.14 ± 0.05 
    β-Hydroxybutyrate (mmol/l) 0.13 ± 0.02 0.18 ± 0.02 0.23 ± 0.02 0.20 ± 0.03 0.17 ± 0.02 
Plasma hormones and adipocyte cytokines      
    Insulin (μU/ml) 31 ± 4 31 ± 4 23 ± 2 27 ± 2 31 ± 4 
    Corticosterone (ng/ml) 176 ± 23 147 ± 19 153 ± 30 180 ± 24 162 ± 31 
    Resistin (ng/ml) 4.8 ± 0.3 4.3 ± 0.4 4.7 ± 0.3 4.5 ± 0.4 4.3 ± 0.3 
    Leptin (ng/ml) 17 ± 3 42 ± 4 26 ± 5§ 46.7 ± 3.1 39 ± 3 

Data are means ± SE (n = 8/group except whole-body fat measurements n = 4–5/group). Whole-body fat content was determined before and at the end of dietary regimen. Epididymal fat pads were dissected on day 15 of dietary treatment and weighed.

*

P < 0.0001,

P < 0.001, and

P < 0.05 indicate statistical difference from control diet;

P < 0.00001,

P < 0.001,

§

P < 0.05 indicate statistical difference from 27% safflower oil diet. CONT, control diet; FISH, isocaloric high-fat diets containing 27, 14.5, or 8% fish oil; SAFF, isocaloric high-fat diet containing 27% safflower oil.

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