Four SNPs of PPARD in combination with the SNP rs8192687 G/A (Gly482Ser) of PGC-1A as predictors for the development of type 2 diabetes by treatment group (logistic regression analysis)
| . | . | Placebo group (n = 414) . | . | Acarbose group (n = 355) . | . | Genotype/treatment interaction . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | OR (95% CI) . | P . | OR (95% CI) . | P . | P . | . | |||
| Model 1 (univariate) | |||||||||
| PPARD rs6902123 | One risk (1) | 1.49 (0.98–2.25) | 0.061 | 0.80 (0.50–1.27) | 0.339 | 0.015† | |||
| PGC-1A rs8192687 | Both risk (2) | 2.56 (1.13–5.80)† | 0.024† | 0.77 (0.32–1.81) | 0.524 | ||||
| 2.92 (1.26–6.75)† | 0.012*† | ||||||||
| Model 2 (univariate) | |||||||||
| PPARD rs2267668 | One risk (1) | 1.51 (0.97–2.36) | 0.067 | 0.70 (0.43–1.14) | 0.153 | 0.027† | |||
| PGC-1A rs8192687 | Both risk (2) | 1.75 (0.97–2.36) | 0.064 | 0.74 (0.39–1.40) | 0.738 | ||||
| Model 3 (univariate) | |||||||||
| PPARD rs2016520 | One risk (1) | 1.49 (0.95–2.33) | 0.083 | 0.68 (0.14–1.12) | 0.132 | 0.032† | |||
| PGC-1A rs8192687 | Both risk (2) | 1.74 (0.97–3.10) | 0.061 | 0.76 (0.41–1.41) | 0.377 | ||||
| Model 4 (univariate) | |||||||||
| PPARD rs3734254 | One risk (1) | 1.63 (1.03–2.57)† | 0.036† | 0.81 (0.49–1.33) | 0.397 | 0.031† | |||
| PGC-1A rs8192687 | Both risk (2) | 2.15 (1.21–3.80)† | 0.009† | 0.90 (0.48–1.69) | 0.743 | ||||
| 2.30 (1.27–4.15)† | 0.006*† | ||||||||
| . | . | Placebo group (n = 414) . | . | Acarbose group (n = 355) . | . | Genotype/treatment interaction . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | OR (95% CI) . | P . | OR (95% CI) . | P . | P . | . | |||
| Model 1 (univariate) | |||||||||
| PPARD rs6902123 | One risk (1) | 1.49 (0.98–2.25) | 0.061 | 0.80 (0.50–1.27) | 0.339 | 0.015† | |||
| PGC-1A rs8192687 | Both risk (2) | 2.56 (1.13–5.80)† | 0.024† | 0.77 (0.32–1.81) | 0.524 | ||||
| 2.92 (1.26–6.75)† | 0.012*† | ||||||||
| Model 2 (univariate) | |||||||||
| PPARD rs2267668 | One risk (1) | 1.51 (0.97–2.36) | 0.067 | 0.70 (0.43–1.14) | 0.153 | 0.027† | |||
| PGC-1A rs8192687 | Both risk (2) | 1.75 (0.97–2.36) | 0.064 | 0.74 (0.39–1.40) | 0.738 | ||||
| Model 3 (univariate) | |||||||||
| PPARD rs2016520 | One risk (1) | 1.49 (0.95–2.33) | 0.083 | 0.68 (0.14–1.12) | 0.132 | 0.032† | |||
| PGC-1A rs8192687 | Both risk (2) | 1.74 (0.97–3.10) | 0.061 | 0.76 (0.41–1.41) | 0.377 | ||||
| Model 4 (univariate) | |||||||||
| PPARD rs3734254 | One risk (1) | 1.63 (1.03–2.57)† | 0.036† | 0.81 (0.49–1.33) | 0.397 | 0.031† | |||
| PGC-1A rs8192687 | Both risk (2) | 2.15 (1.21–3.80)† | 0.009† | 0.90 (0.48–1.69) | 0.743 | ||||
| 2.30 (1.27–4.15)† | 0.006*† | ||||||||
Adjustment for age, sex, smoking, weight at baseline, and weight change.
Statistically significant. (rs6902123 T/C; rs2016520 T/C; rs3734254 T/C) + rs8192687 G/A genotypes were coded as (0) = TT + GG; (1) = TT + (GA + AA) and (TC + CC) + GG; (2) = (TC + CC) + (GA + AA). rs2267668 A/G + rs8192687 G/A genotypes were coded as (0) = AA + GG; (1) = AA + (GA + AA) and (AG + GG) + GG; (2) = (AG + GG) + (GA + AA).