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TABLE 1

Characteristics of patient samples

Populationn (male/female)Age (years)BMI (kg/m2)Fasting plasma glucose (mmol/l)HbA1c (%)* or plasma glucose at 2-h OGTT (mmol/l)†
Scandinavia trios      
    Probands 168/153 39 ± 9 27 ± 5 7.2 ± 2.6 8.5 ± 2.9† 
    Parents 236/236     
Sibships      
    Diabetes/severe IGT sib 280/329 65 ± 10 29 ± 5 9.3 ± 3.3 14.3 ± 5.6† 
    NGT sib 275/305 62 ± 10 26 ± 3 5.4 ± 0.4 6.0 ± 1.1† 
Scandinavia case/control      
    Diabetes/severe IGT 252/219 60 ± 10 28 ± 5 9.8 ± 3.4 15.0 ± 5.3† 
    NGT 254/217 60 ± 10 27 ± 4 6.2 ± 1.8 6.8 ± 2.8† 
Sweden case/control      
    Diabetes/severe IGT 267/247 66 ± 12 28 ± 4 9.6 ± 2.9 6.5 ± 1.5* 
    NGT 267/247 66 ± 12 28 ± 4 5.5 ± 0.7 ND 
Canada case/control      
    Diabetes 70/57 53 ± 8 29 ± 5 6.4 ± 1.8 12.8 ± 2.1† 
    NGT 70/57 52 ± 8 29 ± 4 5.1 ± 0.6 6.1 ± 1.1† 
U.S. case/control      
    Diabetes 644/582 63 ± 11 33 ± 7 9.8 ± 3.0 8.0 ± 3.1* 
    NGT 644/582 61 ± 10 27 ± 5 5.1 ± 0.9 ND 
Poland case/control      
    Diabetes 422/587 62 ± 10 30 ± 5 8.9 ± 4.0 7.9 ± 1.3* 
    NGT 422/587 59 ± 7 26 ± 4 4.8 ± 1.2 ND 
Populationn (male/female)Age (years)BMI (kg/m2)Fasting plasma glucose (mmol/l)HbA1c (%)* or plasma glucose at 2-h OGTT (mmol/l)†
Scandinavia trios      
    Probands 168/153 39 ± 9 27 ± 5 7.2 ± 2.6 8.5 ± 2.9† 
    Parents 236/236     
Sibships      
    Diabetes/severe IGT sib 280/329 65 ± 10 29 ± 5 9.3 ± 3.3 14.3 ± 5.6† 
    NGT sib 275/305 62 ± 10 26 ± 3 5.4 ± 0.4 6.0 ± 1.1† 
Scandinavia case/control      
    Diabetes/severe IGT 252/219 60 ± 10 28 ± 5 9.8 ± 3.4 15.0 ± 5.3† 
    NGT 254/217 60 ± 10 27 ± 4 6.2 ± 1.8 6.8 ± 2.8† 
Sweden case/control      
    Diabetes/severe IGT 267/247 66 ± 12 28 ± 4 9.6 ± 2.9 6.5 ± 1.5* 
    NGT 267/247 66 ± 12 28 ± 4 5.5 ± 0.7 ND 
Canada case/control      
    Diabetes 70/57 53 ± 8 29 ± 5 6.4 ± 1.8 12.8 ± 2.1† 
    NGT 70/57 52 ± 8 29 ± 4 5.1 ± 0.6 6.1 ± 1.1† 
U.S. case/control      
    Diabetes 644/582 63 ± 11 33 ± 7 9.8 ± 3.0 8.0 ± 3.1* 
    NGT 644/582 61 ± 10 27 ± 5 5.1 ± 0.9 ND 
Poland case/control      
    Diabetes 422/587 62 ± 10 30 ± 5 8.9 ± 4.0 7.9 ± 1.3* 
    NGT 422/587 59 ± 7 26 ± 4 4.8 ± 1.2 ND 

Data are means ± SD. Plasma glucose was measured at baseline (fasting) and 2 h after an OGTT. Severe impaired glucose tolerance (IGT) was defined as an OGTT 2-h blood glucose ≥8.5 mmol/l but <10.0 mmol/l. ND, not determined; NGT, normal glucose tolerance.

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