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TABLE 2

Genotype counts for the KLF11 Q62R polymorphism in the various subsamples

Family basedTransmitted
Untransmitted
MAFOR (95% CI)P value
Trios 27
 
36
 
0.09 0.75 (0.46–1.23) 0.26 
Family basedTransmitted
Untransmitted
MAFOR (95% CI)P value
Trios 27
 
36
 
0.09 0.75 (0.46–1.23) 0.26 
Discordant sibsExcess in affected
Excess in unaffected
 23 25 0.09 0.92 (0.52–1.62) 0.77 
Discordant sibsExcess in affected
Excess in unaffected
 23 25 0.09 0.92 (0.52–1.62) 0.77 
Case/controlG/G (R/R)A/G (Q/R)A/A (Q/Q)
Scandinavia       
    Case subjects 74 388 0.09   
    Control subjects 66 394 0.09 1.08 (0.79–1.48) 0.64 
Sweden       
    Case subjects 88 409 0.10   
    Control subjects 90 410 0.10 1.07 (0.80–1.43) 0.66 
Canada       
    Case subjects 23 86 0.12   
    Control subjects 22 83 0.14 0.87 (0.50–1.51) 0.62 
GCI U.S.       
    Case subjects 16 253 938 0.12   
    Control subjects 15 263 920 0.12 0.96 (0.81–1.14) 0.65 
GCI Poland       
    Case subjects 18 175 807 0.11   
    Control subjects 11 193 793 0.11 0.98 (0.80–1.19) 0.81 
Overall     0.97 (0.88–1.08) 0.63 
Case/controlG/G (R/R)A/G (Q/R)A/A (Q/Q)
Scandinavia       
    Case subjects 74 388 0.09   
    Control subjects 66 394 0.09 1.08 (0.79–1.48) 0.64 
Sweden       
    Case subjects 88 409 0.10   
    Control subjects 90 410 0.10 1.07 (0.80–1.43) 0.66 
Canada       
    Case subjects 23 86 0.12   
    Control subjects 22 83 0.14 0.87 (0.50–1.51) 0.62 
GCI U.S.       
    Case subjects 16 253 938 0.12   
    Control subjects 15 263 920 0.12 0.96 (0.81–1.14) 0.65 
GCI Poland       
    Case subjects 18 175 807 0.11   
    Control subjects 11 193 793 0.11 0.98 (0.80–1.19) 0.81 
Overall     0.97 (0.88–1.08) 0.63 

The transmission disequilibrium test and the discordant allele test were performed in the Scandinavian trios and the discordant sibpairs, respectively. ORs were calculated for the minor allele (G, coding for arginine) versus the major allele (A, coding for glutamine) and pooled by Mantel-Haenszel analysis. MAF, minor allele frequency.

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