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TABLE 1

Arterial plasma C-peptide and hepatic sinusoidal glucagon levels in overnight-fasted conscious dogs administered insulin by inhalation (n = 7) or matched IVC infusion (n = 6)

t (min)Arterial plasma C-peptide level (ng/ml)
Hepatic sinusoidal glucagon level (pg/ml)
InhalationIVC infusionInhalationIVC infusion
−20 0.34 ± 0.06 0.26 ± 0.03 61 ± 8 49 ± 5 
0.43 ± 0.13 0.37 ± 0.09 64 ± 9 50 ± 8 
0.56 ± 0.11 0.44 ± 0.12 72 ± 9 60 ± 5 
20 0.17 ± 0.05 0.26 ± 0.18 58 ± 6 60 ± 6 
35 0.12 ± 0.05 0.09 ± 0.04 50 ± 5 49 ± 6 
65 0.12 ± 0.05 0.05 ± 0.02 44 ± 5 42 ± 4 
95 0.11 ± 0.05 0.06 ± 0.03 43 ± 4 38 ± 4 
125 0.12 ± 0.06 0.06 ± 0.02 42 ± 4 32 ± 4 
185 0.11 ± 0.06 0.06 ± 0.03 39 ± 5 33 ± 3 
245 0.11 ± 0.05 0.05 ± 0.03 38 ± 4 33 ± 3 
t (min)Arterial plasma C-peptide level (ng/ml)
Hepatic sinusoidal glucagon level (pg/ml)
InhalationIVC infusionInhalationIVC infusion
−20 0.34 ± 0.06 0.26 ± 0.03 61 ± 8 49 ± 5 
0.43 ± 0.13 0.37 ± 0.09 64 ± 9 50 ± 8 
0.56 ± 0.11 0.44 ± 0.12 72 ± 9 60 ± 5 
20 0.17 ± 0.05 0.26 ± 0.18 58 ± 6 60 ± 6 
35 0.12 ± 0.05 0.09 ± 0.04 50 ± 5 49 ± 6 
65 0.12 ± 0.05 0.05 ± 0.02 44 ± 5 42 ± 4 
95 0.11 ± 0.05 0.06 ± 0.03 43 ± 4 38 ± 4 
125 0.12 ± 0.06 0.06 ± 0.02 42 ± 4 32 ± 4 
185 0.11 ± 0.06 0.06 ± 0.03 39 ± 5 33 ± 3 
245 0.11 ± 0.05 0.05 ± 0.03 38 ± 4 33 ± 3 
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