Heritability (h2) of different estimates of GFR in various groups of relatives
| Groups of relatives . | Relative pairs (n) . | Estimates of GFR . | . | . | ||
|---|---|---|---|---|---|---|
| . | . | CC-GFR*† . | CG-GFR*† . | MDRD-GFR*† . | ||
| Diabetic subjects only | 1,202 | 0.45 ± 0.11 (P < 1 × 105) | 0.47 ± 0.12 (P < 1x10−5) | 0.29 ± 0.11 (P < 0.001) | ||
| Nondiabetic subjects | 1,678 | 0.36 ± 0.13 (P < 1 × 10−3) | 0.15 ± 0.11 (NS) | 0.22 ± 0.12 (P < 0.05) | ||
| All relatives | 5,187 | 0.28 ± 0.06 (P < 1 × 10−7) | 0.31 ± 0.07 (P < 1 × 10−7) | 0.28 ± 0.07 (P < 1 × 10−6) | ||
| Groups of relatives . | Relative pairs (n) . | Estimates of GFR . | . | . | ||
|---|---|---|---|---|---|---|
| . | . | CC-GFR*† . | CG-GFR*† . | MDRD-GFR*† . | ||
| Diabetic subjects only | 1,202 | 0.45 ± 0.11 (P < 1 × 105) | 0.47 ± 0.12 (P < 1x10−5) | 0.29 ± 0.11 (P < 0.001) | ||
| Nondiabetic subjects | 1,678 | 0.36 ± 0.13 (P < 1 × 10−3) | 0.15 ± 0.11 (NS) | 0.22 ± 0.12 (P < 0.05) | ||
| All relatives | 5,187 | 0.28 ± 0.06 (P < 1 × 10−7) | 0.31 ± 0.07 (P < 1 × 10−7) | 0.28 ± 0.07 (P < 1 × 10−6) | ||
Data are h2 ± SE (P value).
Covariates used for adjustment (see research design and methods).
Genetic (σG± SE) and environmental (σE± SE) SDs relating to the h2 ± SE estimates by group of relatives and estimate of GFR. Diabetic subjects only: CC-GFR = σG= 18.77 ± 2.68, σE= 20.58 ± 1.96; CG-GFR = σG= 22.53 ± 3.33, σE= 23.70 ± 2.48; and MDRD-GFR = σG= 13.77 ± 2.74, σE= 21.56 ± 1.64. Nondiabetic subjects only: CC-GFR = σG= 12.09 ± 2.35, σE= 16.25 ± 1.56; CG-GFR = σG= 11.12 ± 4.22, σE= 26.77 ± 1.86; and MDRD-GFR = σG= 10.69 ± 3.01, σE= 20.29 ± 1.57. All relatives: CC-GFR = σG= 13.23 ± 1.63, σE= 21.12 ± 0.95; CG-GFR = σG= 17.23 ± 2.10, σE= 25.52 ± 1.25; and MDRD-GFR = σG= 12.95 ± 1.73, σE= 20.81 ± 0.98.