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TABLE 2

Nonparametric correlations (Spearman’s r) between hepatic gene expression (as expressed relative to housekeeping gene mRNA expression) and the amount of liver fat and liver fat adjusted for BMI

GeneLiver fatLiver fat adjusted for BMINAFL−NAFL+Fold difference
PAI1 0.32 0.05 2.12 ± 0.9 1.85 ± 0.28 0.9 
PPARγ 0.39 0.22 0.13 ± 0.01 0.17 ± 0.01 1.3 
PPARγ2 0.64* 0.34 0.05 ± 0.01 0.15 ± 0.02 2.8 
PGC1 −0.19 −0.19 5.6 ± 1.37 3.29 ± 0.56 0.6 
PPARα 0.06 −0.05 4.58 ± 0.97 4.31 ± 0.52 0.9 
PPARδ 0.29 0.1 0.18 ± 0.03 0.24 ± 0.03 1.3 
ADIPOR1 −0.08 −0.14 1.23 ± 0.1 1.29 ± 0.13 1.1 
ADIPOR2 0.05 0.03 3.01 ± 0.53 3.03 ± 0.46 1.0 
HMGCS2 −0.07 −0.17 6.36 ± 0.71 5.96 ± 0.44 0.9 
IGFBP1 −0.11 −0.28 4.88 ± 1.38 6.76 ± 2.5 1.4 
CD68 0.14 0.17 0.17 ± 0.03 0.2 ± 0.02 1.1 
MCP-1 0.61§ 0.45 0.32 ± 0.05 0.57 ± 0.05§ 1.8 
MIP-1α 0.42 0.36 0.03 ± 0.01 0.04 ± 0.01 1.6 
SCD 0.18 0.22 0.44 ± 0.13 0.48 ± 0.09 1.1 
ACSL4 0.53§ 0.43 0.11 ± 0.05 0.31 ± 0.07 2.8 
CPT1A 0.24 0.11 2.69 ± 0.53 3.39 ± 0.44 1.3 
ACACA 0.27 0.2 1.39 ± 0.31 1.89 ± 0.18 1.4 
FATP5 −0.16 −0.22 8.57 ± 0.87 7.81 ± 0.7 0.9 
FABP4 0.83 0.76 0.002 ± 0.001 0.009 ± 0.001§ 3.9 
FABP5 0.74* 0.62§ 0.016 ± 0.003 0.039 ± 0.008 2.5 
LPL 0.73* 0.66* 0.002 ± 0.001 0.006 ± 0.002 3.6 
GeneLiver fatLiver fat adjusted for BMINAFL−NAFL+Fold difference
PAI1 0.32 0.05 2.12 ± 0.9 1.85 ± 0.28 0.9 
PPARγ 0.39 0.22 0.13 ± 0.01 0.17 ± 0.01 1.3 
PPARγ2 0.64* 0.34 0.05 ± 0.01 0.15 ± 0.02 2.8 
PGC1 −0.19 −0.19 5.6 ± 1.37 3.29 ± 0.56 0.6 
PPARα 0.06 −0.05 4.58 ± 0.97 4.31 ± 0.52 0.9 
PPARδ 0.29 0.1 0.18 ± 0.03 0.24 ± 0.03 1.3 
ADIPOR1 −0.08 −0.14 1.23 ± 0.1 1.29 ± 0.13 1.1 
ADIPOR2 0.05 0.03 3.01 ± 0.53 3.03 ± 0.46 1.0 
HMGCS2 −0.07 −0.17 6.36 ± 0.71 5.96 ± 0.44 0.9 
IGFBP1 −0.11 −0.28 4.88 ± 1.38 6.76 ± 2.5 1.4 
CD68 0.14 0.17 0.17 ± 0.03 0.2 ± 0.02 1.1 
MCP-1 0.61§ 0.45 0.32 ± 0.05 0.57 ± 0.05§ 1.8 
MIP-1α 0.42 0.36 0.03 ± 0.01 0.04 ± 0.01 1.6 
SCD 0.18 0.22 0.44 ± 0.13 0.48 ± 0.09 1.1 
ACSL4 0.53§ 0.43 0.11 ± 0.05 0.31 ± 0.07 2.8 
CPT1A 0.24 0.11 2.69 ± 0.53 3.39 ± 0.44 1.3 
ACACA 0.27 0.2 1.39 ± 0.31 1.89 ± 0.18 1.4 
FATP5 −0.16 −0.22 8.57 ± 0.87 7.81 ± 0.7 0.9 
FABP4 0.83 0.76 0.002 ± 0.001 0.009 ± 0.001§ 3.9 
FABP5 0.74* 0.62§ 0.016 ± 0.003 0.039 ± 0.008 2.5 
LPL 0.73* 0.66* 0.002 ± 0.001 0.006 ± 0.002 3.6 

Data are means ± SE. mRNA concentration of selected genes in the liver in control subjects and subjects with NAFL.

*

P < 0.001,

P < 0.05,

0.1 > P > 0.05,

§

P < 0.01,

P < 0.0001 for correlation or control versus NAFL.

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