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TABLE 2

Comparison of the age, BMI, ideal WFH, waist-to-hip ratio, and body fat of each proband with a group of control subjects of similar age, same sex, and 6K/81I carrier status

Met134IleControl subjects*Ala70ThrControl subjectsIle183AsnControl subjectsProbandsControl subjectsP
n  25  37  110  
Age (years) 11.9 11.1 ± 3.2 11.7 11.1 ± 1.3 13.1 13.6 ± 1.9 12.3 ± 0.7 12.3 ± 1.7 0.929 
BMI (kg/m231.6 30.7 ± 3.6 35 32 ± 3.6 36.6 33.1 ± 5.7 34.4 ± 2.6 33.5 ± 5.1 0.769 
WFH (%) 178 166.1 ± 19.8 173 166.5 ± 15.8 182 180.5 ± 22.9 177.7 ± 4.5 171 ± 23.2 0.633 
Waist-to-hip ratio 0.990 0.890 ± 0.072 0.972 0.950 ± 0.062 0.954 0.870 ± 0.035 0.981 ± 0.013 0.926 ± 0.072 0.281 
Body fat (%) 57.3 47 ± 6.7 40 41.1 ± 3.9 61.3 58.4 ± 12.5 52.2 ± 12.5 47.8 ± 9.4 0.428 
Leptin (μg/l) 116.4 53.7 ± 36.4 71.9 45.8 ± 29.6 142.8 100.9 ± 75.1 110.4 ± 35.8 54.7 ± 39.7 0.018* 
Met134IleControl subjects*Ala70ThrControl subjectsIle183AsnControl subjectsProbandsControl subjectsP
n  25  37  110  
Age (years) 11.9 11.1 ± 3.2 11.7 11.1 ± 1.3 13.1 13.6 ± 1.9 12.3 ± 0.7 12.3 ± 1.7 0.929 
BMI (kg/m231.6 30.7 ± 3.6 35 32 ± 3.6 36.6 33.1 ± 5.7 34.4 ± 2.6 33.5 ± 5.1 0.769 
WFH (%) 178 166.1 ± 19.8 173 166.5 ± 15.8 182 180.5 ± 22.9 177.7 ± 4.5 171 ± 23.2 0.633 
Waist-to-hip ratio 0.990 0.890 ± 0.072 0.972 0.950 ± 0.062 0.954 0.870 ± 0.035 0.981 ± 0.013 0.926 ± 0.072 0.281 
Body fat (%) 57.3 47 ± 6.7 40 41.1 ± 3.9 61.3 58.4 ± 12.5 52.2 ± 12.5 47.8 ± 9.4 0.428 
Leptin (μg/l) 116.4 53.7 ± 36.4 71.9 45.8 ± 29.6 142.8 100.9 ± 75.1 110.4 ± 35.8 54.7 ± 39.7 0.018* 

Data are means ± SD.

*

Females selected based on age 3 years above or below 11.9 years, and heterozygous for 6K/81I, because subject with Met134Ile is heterozygous for 6K/81I.

Males selected based on age 2 years above or below 11.7 years and with wild-type MC3R alleles 6T/81V, because subject with Ala70Thr is homozygous for wild-type allele.

Females selected based on age 2 years above or below 13.1 years and homozygous for 6K/81I, because subject with Ile183Asn is homozygous for 6K/81I. All control subjects that fulfilled age criteria are included in the analysis.

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