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TABLE 1

Responses from clusters identified by SPM

Aware
Unaware
Aware
Unaware
5 mmol/l2.6 mmol/l5 mmol/l2.6 mmol/lHypoglycemic-euglycemicHypoglycemic-euglycemic
Left ventral striatum* 85.22 ± 1.57 93.61 ± 1.15 85.63 ± 4.52 90.28 ± 4.20 8.39 ± 1.57 4.65 ± 2.18 
Right ventral striatum 84.90 ± 3.37 92.98 ± 3.05 86.16 ± 4.99 91.90 ± 4.63 8.09 ± 1.03 5.73 ± 3.39 
Occipital cortex* 96.28 ± 6.61 107.37 ± 9.17 93.76 ± 4.46 98.21 ± 3.77 11.09 ± 3.78 4.45 ± 2.66 
Left cerebellum 63.36 ± 3.95 57.92 ± 9.89 63.92 ± 4.43 60.59 ± 5.67 −5.44 ± 10.53 −3.33 ± 8.29 
Right cerebellum* 71.10 ± 3.83 77.77 ± 5.30 71.03 ± 4.55 67.63 ± 5.20 6.67 ± 4.70 −3.39 ± 3.37 
Brainstem* 45.20 ± 4.28 45.75 ± 3.60 49.27 ± 3.03 42.78 ± 3.79 0.55 ± 2.34 −6.48 ± 2.38 
Right orbitofrontal cortex* 82.38 ± 8.60 74.25 ± 10.99 80.84 ± 4.41 82.47 ± 3.30 −8.13 ± 3.56 1.64 ± 3.17 
Left amygdala* 60.55 ± 2.21 63.11 ± 2.48 61.26 ± 3.33 57.41 ± 3.18 2.56 ± 1.28 −3.85 ± 2.35 
Left white matter 45.80 ± 4.66 39.01 ± 3.87 46.54 ± 1.82 38.79 ± 1.49 −6.79 ± 1.33 −7.75 ± 2.12 
Right white matter 42.75 ± 3.16 36.09 ± 3.58 44.20 ± 2.45 36.10 ± 2.70 −6.65 ± 1.30 −8.10 ± 1.89 
Hypothalamus, parahippocampal gyrus 34.90 ± 1.15 28.91 ± 2.13 37.62 ± 2.25 29.09 ± 1.52 −5.93 ± 2.09 −8.53 ± 1.39 
Aware
Unaware
Aware
Unaware
5 mmol/l2.6 mmol/l5 mmol/l2.6 mmol/lHypoglycemic-euglycemicHypoglycemic-euglycemic
Left ventral striatum* 85.22 ± 1.57 93.61 ± 1.15 85.63 ± 4.52 90.28 ± 4.20 8.39 ± 1.57 4.65 ± 2.18 
Right ventral striatum 84.90 ± 3.37 92.98 ± 3.05 86.16 ± 4.99 91.90 ± 4.63 8.09 ± 1.03 5.73 ± 3.39 
Occipital cortex* 96.28 ± 6.61 107.37 ± 9.17 93.76 ± 4.46 98.21 ± 3.77 11.09 ± 3.78 4.45 ± 2.66 
Left cerebellum 63.36 ± 3.95 57.92 ± 9.89 63.92 ± 4.43 60.59 ± 5.67 −5.44 ± 10.53 −3.33 ± 8.29 
Right cerebellum* 71.10 ± 3.83 77.77 ± 5.30 71.03 ± 4.55 67.63 ± 5.20 6.67 ± 4.70 −3.39 ± 3.37 
Brainstem* 45.20 ± 4.28 45.75 ± 3.60 49.27 ± 3.03 42.78 ± 3.79 0.55 ± 2.34 −6.48 ± 2.38 
Right orbitofrontal cortex* 82.38 ± 8.60 74.25 ± 10.99 80.84 ± 4.41 82.47 ± 3.30 −8.13 ± 3.56 1.64 ± 3.17 
Left amygdala* 60.55 ± 2.21 63.11 ± 2.48 61.26 ± 3.33 57.41 ± 3.18 2.56 ± 1.28 −3.85 ± 2.35 
Left white matter 45.80 ± 4.66 39.01 ± 3.87 46.54 ± 1.82 38.79 ± 1.49 −6.79 ± 1.33 −7.75 ± 2.12 
Right white matter 42.75 ± 3.16 36.09 ± 3.58 44.20 ± 2.45 36.10 ± 2.70 −6.65 ± 1.30 −8.10 ± 1.89 
Hypothalamus, parahippocampal gyrus 34.90 ± 1.15 28.91 ± 2.13 37.62 ± 2.25 29.09 ± 1.52 −5.93 ± 2.09 −8.53 ± 1.39 

Data are means ± SD of tracer uptake expressed as percent of a global mean (50) at different blood glucose levels (5 and 2.6 mmol/l) and of change between hypoglycemic and euglycemic conditions. Significant difference of the effect of condition (hypoglycemia) between the two groups (aware and unaware subjects),

*

P < 0.01;

P < 0.05.

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