American Diabetes Association

TABLE 2

Characteristics of clusters identified by SPM at statistical threshold of P < 0.001

	Cluster size	T (peak value in cluster)	P (corrected cluster level)	x	y	z
Increased uptake (across both groups)
Left ventral striatum	749	16.65	8.3e-7	−22	2	7
Right ventral striatum	686	9.89	2.1e-6	18	12	3
Occipital cortex	2,008	8.94	1.5e-13	6	−81	17
Decreased uptake (across both groups)
White matter	20,570	17.75	0	20	28	13
Left inferior frontal gyrus	313	9.45	0.0013	−55	25	1
Right inferior frontal gyrus	356	8.46	0.00057	59	17	−1
Right anterior white matter^*	845	17.75	1.0e-14	20	28	13
Right periventricular white matter^*	2,646	16.30	0	24	−31	38
Brainstem^*	2,427	16.27	0	4	−7	−16
Left periventricular white matter^*	4,864	14.75	0	−16	−35	29
Left inferior frontal gyrus^*	119	9.45	0.00041	−55	25	1
Greater increase in aware than in unaware subjects
Occipital cortex	365	6.60	0.0004	−2	−93	3
Left amygdala^†	305	6.65	NS	−30	1	−15
Occipital cortex^†	1,851	6.60	6.5e-5	−2	−93	3
Left ventral striatum^†	196	5.54	NS	−24	0	7
Left cerebellum^†	191	5.24	NS	−46	−46	−21
Medial cerebellum/brainstem^†	2,861	5.24	6.8e-7	6	−42	−18
Greater decrease in aware than in unaware subjects
Brodmann areas 10, 11, and 47 (right)^†	1,071	5.48	0.0041	36	32	−13
Brodmann areas 10, 45, and 46 (right)^†	414	4.37	NS	51	30	17
Brodmann areas 8 and 9 (right)^†	214	4.22	NS	24	23	41

	Cluster size	T (peak value in cluster)	P (corrected cluster level)	x	y	z
Increased uptake (across both groups)
Left ventral striatum	749	16.65	8.3e-7	−22	2	7
Right ventral striatum	686	9.89	2.1e-6	18	12	3
Occipital cortex	2,008	8.94	1.5e-13	6	−81	17
Decreased uptake (across both groups)
White matter	20,570	17.75	0	20	28	13
Left inferior frontal gyrus	313	9.45	0.0013	−55	25	1
Right inferior frontal gyrus	356	8.46	0.00057	59	17	−1
Right anterior white matter^*	845	17.75	1.0e-14	20	28	13
Right periventricular white matter^*	2,646	16.30	0	24	−31	38
Brainstem^*	2,427	16.27	0	4	−7	−16
Left periventricular white matter^*	4,864	14.75	0	−16	−35	29
Left inferior frontal gyrus^*	119	9.45	0.00041	−55	25	1
Greater increase in aware than in unaware subjects
Occipital cortex	365	6.60	0.0004	−2	−93	3
Left amygdala^†	305	6.65	NS	−30	1	−15
Occipital cortex^†	1,851	6.60	6.5e-5	−2	−93	3
Left ventral striatum^†	196	5.54	NS	−24	0	7
Left cerebellum^†	191	5.24	NS	−46	−46	−21
Medial cerebellum/brainstem^†	2,861	5.24	6.8e-7	6	−42	−18
Greater decrease in aware than in unaware subjects
Brodmann areas 10, 11, and 47 (right)^†	1,071	5.48	0.0041	36	32	−13
Brodmann areas 10, 45, and 46 (right)^†	414	4.37	NS	51	30	17
Brodmann areas 8 and 9 (right)^†	214	4.22	NS	24	23	41

Clusters of voxels reaching significance, P < 0.001 (uncorrected) and minimum cluster size of 100 voxels (unless otherwise stated). T is peak t statistic within cluster; P is corrected for the cluster (not the voxel). Coordinates of the peak voxel are given in Talairach space.

Threshold of P < 0.0001, cluster size >100;

†

P < 0.01, cluster size >100. NS, not significant.

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