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TABLE 2

LPL studies indicate that the underlying cellular events during inactivity (NEAT deficiency) are distinct from the cellular events after exercise training

Inactivity mechanismsExercise mechanisms
Comparison studied for LPL Inactivity (not standing) vs. normal spontaneous intermittent standing/ambulation during nonexercise physical activity Exercise vs. normal nonexercise physical activity (spontaneous intermittent standing/ambulation) 
Fiber type mostly affected Red oxidative muscle fibers have ≥10-fold lower LPL activity during inactivity White glycolytic muscle fibers have 2.5-fold greater LPL activity after exercise 
LPL mRNA involvement No difference in LPL mRNA between inactive and control LPL mRNA expression increases 2.5-fold in multiple glycolytic muscles after exercise 
Evidence of inhibitory pathway Transcription of an inhibitory gene suppresses LPL by a posttranslational mechanism No evidence for inhibitory gene 
Inactivity mechanismsExercise mechanisms
Comparison studied for LPL Inactivity (not standing) vs. normal spontaneous intermittent standing/ambulation during nonexercise physical activity Exercise vs. normal nonexercise physical activity (spontaneous intermittent standing/ambulation) 
Fiber type mostly affected Red oxidative muscle fibers have ≥10-fold lower LPL activity during inactivity White glycolytic muscle fibers have 2.5-fold greater LPL activity after exercise 
LPL mRNA involvement No difference in LPL mRNA between inactive and control LPL mRNA expression increases 2.5-fold in multiple glycolytic muscles after exercise 
Evidence of inhibitory pathway Transcription of an inhibitory gene suppresses LPL by a posttranslational mechanism No evidence for inhibitory gene 

The mechanisms regulating LPL during physical inactivity (“Inactivity mechanisms” column) and during exercise training (“Exercise mechanisms” column) were studied in comparison with the same referent control group (i.e., normal Sprague-Dawley rats with only intermittent and spontaneous nonexercise physical activity). Table is redrawn from refs. 1,2,85.

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