American Diabetes Association

TABLE 1

TDT of PTPN22 C1858T in type 1 diabetic families

All type 1 diabetic patients	Allele transmitted			Transmission of 1858T allele (%)	P value (TDT)^*	P value (heterogeneity) test^†
All type 1 diabetic patients		1858C	1858T	Transmission of 1858T allele (%)	P value (TDT)^*	P value (heterogeneity) test^†
	249	339	57.7	0.0002
Population origin
French	46	51	52.6	0.61	0.54
U.S.	89	127	58.8	0.01
Danish	114	161	58.5	0.005
Parental origin
Father	112	156	58.2	0.007	0.78
Mother	99	145	59.4	0.003
Sex of patient
Male	130	183	58.5	0.003	0.67
Female	119	156	56.7	0.03
Parental affection status
Affected	41	48	53.9	0.46	0.44
Unaffected	206	288	58.3	0.0002
HLA risk status
DR34+	97	128	56.9	0.05	0.80
DR34−	151	208	57.9	0.003
INS risk status
INS+	184	265	59.0	0.0002	0.24
INS−	63	72	53.3	0.43
Unaffected siblings	157	165	51.2	0.66

All type 1 diabetic patients	Allele transmitted			Transmission of 1858T allele (%)	P value (TDT)^*	P value (heterogeneity) test^†
All type 1 diabetic patients		1858C	1858T	Transmission of 1858T allele (%)	P value (TDT)^*	P value (heterogeneity) test^†
	249	339	57.7	0.0002
Population origin
French	46	51	52.6	0.61	0.54
U.S.	89	127	58.8	0.01
Danish	114	161	58.5	0.005
Parental origin
Father	112	156	58.2	0.007	0.78
Mother	99	145	59.4	0.003
Sex of patient
Male	130	183	58.5	0.003	0.67
Female	119	156	56.7	0.03
Parental affection status
Affected	41	48	53.9	0.46	0.44
Unaffected	206	288	58.3	0.0002
HLA risk status
DR34+	97	128	56.9	0.05	0.80
DR34−	151	208	57.9	0.003
INS risk status
INS+	184	265	59.0	0.0002	0.24
INS−	63	72	53.3	0.43
Unaffected siblings	157	165	51.2	0.66

Data are n.

*

Two-sided χ² test. In TDT analyses of multiplex families, all the affected siblings were studied (test of linkage and association).

†

Heterogeneity tests within subgroups.