American Diabetes Association

TABLE 2

Hemodynamic parameters, myocardial perfusion, and MVR

	Scan	HR (beats/min)	RPP (mmHg/min)	MAP (mmHg)	MP (mL · g⁻¹ · min⁻¹)	MVR (mmHg · ml⁻¹ · min⁻¹ · g⁻¹)
Control subjects
Saline	Rest	61 ± 13	7,807 ± 2,478	94 ± 8	0.81 ± 0.23	123 ± 24
	Ado	89 ± 17^*	11,463 ± 2,335^*	92 ± 10	3.25 ± 0.80^*^†	30 ± 6^*
	Ado + Ph	94 ± 19^*	10,717 ± 3,090^*	79 ± 13^*^‡	2.90 ± 0.78^*	29 ± 8^*
l-NAME	Rest	47 ± 5^§^‖	7,086 ± 1,406^‖	114 ± 14^§	0.65 ± 0.15^§	181 ± 38^§
	Ado	68 ± 18^*^§	10,057 ± 2,904^*	110 ± 12^§	2.98 ± 0.75^*	38 ± 7^*^§
	Ado + Ph	77 ± 16^*^§	10,875 ± 2,409^*	102 ± 8^*‡^§	3.31 ± 0.81^*	33 ± 8^*^‡
Diabetic patients
Saline	Rest	68 ± 10	8,996 ± 2,254	96 ± 14	0.93 ± 0.15	106 ± 23
	Ado	87 ± 13^*	10,478 ± 2,576^*	87 ± 12	2.66 ± 0.58^*	34 ± 10^*
	Ado + Ph	89 ± 20^*	9,849 ± 3,788^*	73 ± 14^*^‡	2.19 ± 0.61^*^‡	36 ± 13^*
l-NAME	Rest	55 ± 8^§	8,855 ± 2,464	120 ± 18^§	0.68 ± 0.13^§	181 ± 40^§
	Ado	73 ± 12^*^§	11,694 ± 3,448^*	118 ± 23^§	3.02 ± 0.68^*	41 ± 12^*
	Ado + Ph	79 ± 13^*^¶	11,698 ± 2,749^*	107 ± 17^*‡^§	2.98 ± 0.62^*^§	38 ± 10^*

	Scan	HR (beats/min)	RPP (mmHg/min)	MAP (mmHg)	MP (mL · g⁻¹ · min⁻¹)	MVR (mmHg · ml⁻¹ · min⁻¹ · g⁻¹)
Control subjects
Saline	Rest	61 ± 13	7,807 ± 2,478	94 ± 8	0.81 ± 0.23	123 ± 24
	Ado	89 ± 17^*	11,463 ± 2,335^*	92 ± 10	3.25 ± 0.80^*^†	30 ± 6^*
	Ado + Ph	94 ± 19^*	10,717 ± 3,090^*	79 ± 13^*^‡	2.90 ± 0.78^*	29 ± 8^*
l-NAME	Rest	47 ± 5^§^‖	7,086 ± 1,406^‖	114 ± 14^§	0.65 ± 0.15^§	181 ± 38^§
	Ado	68 ± 18^*^§	10,057 ± 2,904^*	110 ± 12^§	2.98 ± 0.75^*	38 ± 7^*^§
	Ado + Ph	77 ± 16^*^§	10,875 ± 2,409^*	102 ± 8^*‡^§	3.31 ± 0.81^*	33 ± 8^*^‡
Diabetic patients
Saline	Rest	68 ± 10	8,996 ± 2,254	96 ± 14	0.93 ± 0.15	106 ± 23
	Ado	87 ± 13^*	10,478 ± 2,576^*	87 ± 12	2.66 ± 0.58^*	34 ± 10^*
	Ado + Ph	89 ± 20^*	9,849 ± 3,788^*	73 ± 14^*^‡	2.19 ± 0.61^*^‡	36 ± 13^*
l-NAME	Rest	55 ± 8^§	8,855 ± 2,464	120 ± 18^§	0.68 ± 0.13^§	181 ± 40^§
	Ado	73 ± 12^*^§	11,694 ± 3,448^*	118 ± 23^§	3.02 ± 0.68^*	41 ± 12^*
	Ado + Ph	79 ± 13^*^¶	11,698 ± 2,749^*	107 ± 17^*‡^§	2.98 ± 0.62^*^§	38 ± 10^*

Data are means ± SD. Ado, adenosine; Ado + Ph, adenosine with phentolamine; HR, heart rate; MAP, mean arterial pressure; MP, myocardial perfusion.

P < 0.05 vs. rest;

†

P = 0.05, diabetic patients vs. control subjects;

‡

P < 0.01, adenosine vs. adenosine + phentolamine;

P < 0.01, l-NAME vs. saline in same scan sequence (i.e. l-NAME rest vs. saline rest);

‖

P < 0.05, diabetic patients vs. control subjects;

P = 0.03, l-name vs. saline in same scan sequence.