Meta-analysis of the association between SNPs g.−11391G>A, g.+45T→G, and g.+276G→T and circulating adiponectin levels
| Marker . | Study (ref.) . | Subjects (n) . | WMD (95% CI) . | WMD (95% CI) . | P . | P (hetero-geneity) . | P (Publica-tion bias) . |
|---|---|---|---|---|---|---|---|
| g.−11391G→A | A/A+A/G vs. G/G | ||||||
| Fumeron (36)* | 453 | 2.39 (0.43–4.34) | |||||
| Poitou (66)* | 65 | 4.60 (−0.31 to 9.51) | |||||
| Schwarz (50)* | 550 | 1.69 (0.73–2.65) | |||||
| Tanko (81)* | 283 | 6.60 (1.08–12.12) | |||||
| Vasseur (55)* | 703 | 1.12 (0.64–1.60) | |||||
| A/A +A/G vs. G/G | 2,054 | 1.64 (0.88–2.41) | 0.014 | 0.11 | 0.04 | ||
| g.+45T→G | T/G vs. T/T | G/G vs. T/T | |||||
| Fumeron (36)* | 457 | 1.68 (−0.85 to 4.21) | 2.78 (−4.05 to 9.61) | ||||
| Jang (41)† | 902 | 0.01 (−0.55 to 0.57) | 0.49 (−0.35 to 1.33) | ||||
| Lee (43)† | 427 | 2.35 (1.58–3.12) | 1.33 (0.14–2.52) | ||||
| Mackevics (44)* | 1,733 | 0.55 (0.14 to −0.96) | 2.53 (1.17–3.89) | ||||
| Menzaghi (62)* | 399 | 2.80 (−3.63 to 9.23) | −3.00 (−16.09 to 10.09) | ||||
| Pollin (63)‡ | 548 | 1.50 (−0.79 to 3.79) | 3.30 (−2.16 to 8.76) | ||||
| Takahashi (33)† | 142 | −0.50 (−2.16 to 1.16) | −2.10 (−4.31 to 0.11) | ||||
| Takahashi (33)† | 77 | −0.20 (−1.83 to 1.43) | −1.10 (−3.27 to 1.07) | ||||
| Tanko (81)* | 281 | −1.10 (−6.05 to 3.85) | −12.00 (−16.67 to −7.33) | ||||
| Vasseur (55)* | 703 | −0.03 (−0.52 to 0.46) | −0.13 (−1.25 to 0.99) | ||||
| T/G vs. T/T | 5,388 | 0.35 (−0.53 to 1.23) | 0.44 | <0.00001 | 0.48 | ||
| G/G vs. T/T | −0.38 (−2.85 to 2.09) | 0.76 | <0.00001 | 0.28 | |||
| g.+276G→T | G/T vs. G/G | T/T vs. G/G | |||||
| Fumeron (36)* | 452 | −1.36 (−3.43 to 0.71) | −1.66 (−5.60 to 2.28) | ||||
| Hara (34)† | 480 | 1.30 (−0.32 to 2.92) | 3.10 (0.24–5.96) | ||||
| Iwashima (64)† | 312 | 0.40 (−0.15 to 0.95) | −0.50 (−1.38 to 0.38) | ||||
| Jang (41)† | 902 | 0.21 (−0.34 to 0.76) | 1.45 (0.58–2.32) | ||||
| Lee (43)† | 427 | −0.70 (−1.52 to 0.12) | −6.65 (−7.23 to −6.07) | ||||
| Mackevics (44)* | 1,733 | 0.45 (0.11–0.79) | 1.17 (0.56–1.78) | ||||
| Menzaghi (62)* | 403 | 1.80 (−4.23 to 7.83) | 12.70 (2.71–22.69) | ||||
| Mousavinasab (65)* | 244 | 1.60 (0.69–2.51) | 4.60 (2.28–6.92) | ||||
| Pollin (63)‡ | 544 | 0.80 (−1.39 to 2.99) | 3.00 (−0.06 to 6.06) | ||||
| Salmenniemi (49) | 156 | −0.15 (−1.52 to 1.22) | −0.16 (−1.84 to 1.52) | ||||
| Tanko (81)* | 282 | 1.80 (−1.92 to 5.52) | 7.50 (−0.42 to 15.42) | ||||
| Vasseur (55)* | 635 | 0.59 (0.07–1.11) | 0.62 (−0.11 to 1.35) | ||||
| G/T vs. G/G | 6,570 | 0.39 (0.01–0.79) | 0.05 | 0.043 | 0.95 | ||
| T/T vs. G/G | 1.10 (−1.00 to 3.19) | 0.31 | 0.00001 | 0.12 |
| Marker . | Study (ref.) . | Subjects (n) . | WMD (95% CI) . | WMD (95% CI) . | P . | P (hetero-geneity) . | P (Publica-tion bias) . |
|---|---|---|---|---|---|---|---|
| g.−11391G→A | A/A+A/G vs. G/G | ||||||
| Fumeron (36)* | 453 | 2.39 (0.43–4.34) | |||||
| Poitou (66)* | 65 | 4.60 (−0.31 to 9.51) | |||||
| Schwarz (50)* | 550 | 1.69 (0.73–2.65) | |||||
| Tanko (81)* | 283 | 6.60 (1.08–12.12) | |||||
| Vasseur (55)* | 703 | 1.12 (0.64–1.60) | |||||
| A/A +A/G vs. G/G | 2,054 | 1.64 (0.88–2.41) | 0.014 | 0.11 | 0.04 | ||
| g.+45T→G | T/G vs. T/T | G/G vs. T/T | |||||
| Fumeron (36)* | 457 | 1.68 (−0.85 to 4.21) | 2.78 (−4.05 to 9.61) | ||||
| Jang (41)† | 902 | 0.01 (−0.55 to 0.57) | 0.49 (−0.35 to 1.33) | ||||
| Lee (43)† | 427 | 2.35 (1.58–3.12) | 1.33 (0.14–2.52) | ||||
| Mackevics (44)* | 1,733 | 0.55 (0.14 to −0.96) | 2.53 (1.17–3.89) | ||||
| Menzaghi (62)* | 399 | 2.80 (−3.63 to 9.23) | −3.00 (−16.09 to 10.09) | ||||
| Pollin (63)‡ | 548 | 1.50 (−0.79 to 3.79) | 3.30 (−2.16 to 8.76) | ||||
| Takahashi (33)† | 142 | −0.50 (−2.16 to 1.16) | −2.10 (−4.31 to 0.11) | ||||
| Takahashi (33)† | 77 | −0.20 (−1.83 to 1.43) | −1.10 (−3.27 to 1.07) | ||||
| Tanko (81)* | 281 | −1.10 (−6.05 to 3.85) | −12.00 (−16.67 to −7.33) | ||||
| Vasseur (55)* | 703 | −0.03 (−0.52 to 0.46) | −0.13 (−1.25 to 0.99) | ||||
| T/G vs. T/T | 5,388 | 0.35 (−0.53 to 1.23) | 0.44 | <0.00001 | 0.48 | ||
| G/G vs. T/T | −0.38 (−2.85 to 2.09) | 0.76 | <0.00001 | 0.28 | |||
| g.+276G→T | G/T vs. G/G | T/T vs. G/G | |||||
| Fumeron (36)* | 452 | −1.36 (−3.43 to 0.71) | −1.66 (−5.60 to 2.28) | ||||
| Hara (34)† | 480 | 1.30 (−0.32 to 2.92) | 3.10 (0.24–5.96) | ||||
| Iwashima (64)† | 312 | 0.40 (−0.15 to 0.95) | −0.50 (−1.38 to 0.38) | ||||
| Jang (41)† | 902 | 0.21 (−0.34 to 0.76) | 1.45 (0.58–2.32) | ||||
| Lee (43)† | 427 | −0.70 (−1.52 to 0.12) | −6.65 (−7.23 to −6.07) | ||||
| Mackevics (44)* | 1,733 | 0.45 (0.11–0.79) | 1.17 (0.56–1.78) | ||||
| Menzaghi (62)* | 403 | 1.80 (−4.23 to 7.83) | 12.70 (2.71–22.69) | ||||
| Mousavinasab (65)* | 244 | 1.60 (0.69–2.51) | 4.60 (2.28–6.92) | ||||
| Pollin (63)‡ | 544 | 0.80 (−1.39 to 2.99) | 3.00 (−0.06 to 6.06) | ||||
| Salmenniemi (49) | 156 | −0.15 (−1.52 to 1.22) | −0.16 (−1.84 to 1.52) | ||||
| Tanko (81)* | 282 | 1.80 (−1.92 to 5.52) | 7.50 (−0.42 to 15.42) | ||||
| Vasseur (55)* | 635 | 0.59 (0.07–1.11) | 0.62 (−0.11 to 1.35) | ||||
| G/T vs. G/G | 6,570 | 0.39 (0.01–0.79) | 0.05 | 0.043 | 0.95 | ||
| T/T vs. G/G | 1.10 (−1.00 to 3.19) | 0.31 | 0.00001 | 0.12 |
Race/ethnicity:
Caucasian,
Asian,
Old Order Amish. Ref. 33 appears twice for the two different study populations included in that report.