Meta-analysis of the association between SNPs g.+45T→G and g.+276G→T and HOMAIR
| Marker . | Study (ref.) . | Subjects (n) . | WMD (95% CI) . | WMD (95% CI) . | P . | P (hetero-geneity) . | P (publica-tion bias) . |
|---|---|---|---|---|---|---|---|
| g.+45T→G | T/G vs. T/T | G/G vs. T/T | |||||
| Hara (34)† | 480 | −0.04 (−0.19 to 0.11) | 0.04 (−0.20 to 0.28) | ||||
| Jang (41)† | 902 | 0.14 (−0.07 to 0.35) | −0.15 (−0.39 to 0.09) | ||||
| Lee (43)† | 427 | 0.08 (−0.14 to 0.30) | −0.07 (−0.34 to 0.48) | ||||
| Menzaghi (45)* | 399 | −0.10 (−0.30 to 0.10) | −0.18 (−0.57 to 0.21) | ||||
| Nakatani (46)† | 194 | 0.08 (−0.12 to 0.28) | 0.35 (0.00–0.70) | ||||
| Tanko (81)* | 281 | −0.41 (−1.05 to 0.23) | −0.45 (−2.54 to 1.64) | ||||
| Yang (82)† | 245 | −0.40 (−0.97 to 0.17) | −0.83 (−1.44 to −0.22) | ||||
| T/G vs. T/T | 2,928 | −0.02 (−0.12 to 0.08) | 0.71 | 0.27 | 0.10 | ||
| G/G vs. T/T | −0.09 (−0.36 to 0.17) | 0.48 | 0.036 | 0.93 | |||
| g.+276G→T | G/T vs. G/G | T/T vs. G/G | |||||
| Hara (34)† | 480 | −0.16 (−0.30 to −0.02) | −0.42 (−0.66 to −0.18) | ||||
| Jang (41)† | 902 | −0.03 (−0.23 to 0.17) | −0.36 (−0.59 to −0.13) | ||||
| Lee (43)† | 427 | 0.04 (−0.18 to 0.26) | 0.09 (−0.34 to 0.52) | ||||
| Menzaghi (45)* | 403 | −0.23 (−0.44 to −0.02) | −0.35 (−0.65 to −0.05) | ||||
| Nakatani (46)† | 194 | −0.15 (−0.36 to 0.06) | −0.39 (−0.62 to −0.16) | ||||
| Tanko (81)† | 282 | −0.20 (−0.92 to 0.52) | −0.81 (−1.71 to 0.09) | ||||
| G/T vs. G/G | 2,688 | −0.12 (−0.20 to −0.04) | 0.005 | 0.49 | 0.26 | ||
| T/T vs. G/G | −0.36 (−0.47 to −0.24) | <0.0001 | 0.37 | 0.85 |
| Marker . | Study (ref.) . | Subjects (n) . | WMD (95% CI) . | WMD (95% CI) . | P . | P (hetero-geneity) . | P (publica-tion bias) . |
|---|---|---|---|---|---|---|---|
| g.+45T→G | T/G vs. T/T | G/G vs. T/T | |||||
| Hara (34)† | 480 | −0.04 (−0.19 to 0.11) | 0.04 (−0.20 to 0.28) | ||||
| Jang (41)† | 902 | 0.14 (−0.07 to 0.35) | −0.15 (−0.39 to 0.09) | ||||
| Lee (43)† | 427 | 0.08 (−0.14 to 0.30) | −0.07 (−0.34 to 0.48) | ||||
| Menzaghi (45)* | 399 | −0.10 (−0.30 to 0.10) | −0.18 (−0.57 to 0.21) | ||||
| Nakatani (46)† | 194 | 0.08 (−0.12 to 0.28) | 0.35 (0.00–0.70) | ||||
| Tanko (81)* | 281 | −0.41 (−1.05 to 0.23) | −0.45 (−2.54 to 1.64) | ||||
| Yang (82)† | 245 | −0.40 (−0.97 to 0.17) | −0.83 (−1.44 to −0.22) | ||||
| T/G vs. T/T | 2,928 | −0.02 (−0.12 to 0.08) | 0.71 | 0.27 | 0.10 | ||
| G/G vs. T/T | −0.09 (−0.36 to 0.17) | 0.48 | 0.036 | 0.93 | |||
| g.+276G→T | G/T vs. G/G | T/T vs. G/G | |||||
| Hara (34)† | 480 | −0.16 (−0.30 to −0.02) | −0.42 (−0.66 to −0.18) | ||||
| Jang (41)† | 902 | −0.03 (−0.23 to 0.17) | −0.36 (−0.59 to −0.13) | ||||
| Lee (43)† | 427 | 0.04 (−0.18 to 0.26) | 0.09 (−0.34 to 0.52) | ||||
| Menzaghi (45)* | 403 | −0.23 (−0.44 to −0.02) | −0.35 (−0.65 to −0.05) | ||||
| Nakatani (46)† | 194 | −0.15 (−0.36 to 0.06) | −0.39 (−0.62 to −0.16) | ||||
| Tanko (81)† | 282 | −0.20 (−0.92 to 0.52) | −0.81 (−1.71 to 0.09) | ||||
| G/T vs. G/G | 2,688 | −0.12 (−0.20 to −0.04) | 0.005 | 0.49 | 0.26 | ||
| T/T vs. G/G | −0.36 (−0.47 to −0.24) | <0.0001 | 0.37 | 0.85 |
Race/ethnicity:
Caucasian,
Asian.