Meta-analysis of the association between SNPs g.−11391G→A, g.−11377C→G, g.+45T→G, and g.+276G>T and type 2 diabetes
| Marker . | Study (ref.) . | Type 2 diabetic subjects (n) . | Control subjects (n) . | OR (95% CI) . | OR (95% CI) . | P . | P (hetero-geneity) . | P (publica-tion bias) . |
|---|---|---|---|---|---|---|---|---|
| g.−11391G→A | G/A vs. G/G | A/A vs. G/G | ||||||
| Fumeron (36)* | 177 | 4,510 | 0.95 (0.63–1.42) | 0.58 (0.08–4.28) | ||||
| Hara (34)† | 384 | 480 | 0.82 (0.44–1.52) | 1.24 (0.02–62.48) | ||||
| Gibson (37)* | 775 | 944 | 1.22 (0.95–1.57) | 1.45 (0.52–4.01) | ||||
| Stenvinkel (79)* | 30 | 145 | 1.59 (0.44–5.72) | 0.53 (0.03–10.16) | ||||
| Vasseur (54)* | 620 | 690 | 1.21 (0.91–1.62) | 2.08 (0.69–6.26) | ||||
| Vasseur (55)* | 231 | 270 | 1.22 (0.95–1.57) | 1.42 (0.38–5.36) | ||||
| G/A vs. G/G | 2,217 | 7,039 | 1.10 (0.94–1.28) | 0.23 | 0.48 | 0.31 | ||
| A/A vs. G/G | 1.41 (0.78–2.58) | 0.26 | 0.89 | 0.08 | ||||
| g.−11377C→G | C/G vs. C/C | G/G vs. C/C | ||||||
| Fumeron (36)* | 175 | 4,502 | 1.10 (0.80–1.51) | 0.68 (0.34–1.35) | ||||
| Gibson (37)* | 812 | 1,044 | 1.02 (0.84–1.24) | 1.05 (0.73–1.51) | ||||
| Gu (39)* | 103 | 486 | 0.78 (0.49–1.24) | 0.88 (0.43–1.80) | ||||
| Hara (34)† | 384 | 480 | 0.81 (0.61–1.08) | 0.74 (0.43–1.27) | ||||
| Hu (40)* | 642 | 995 | 1.00 (0.82–1.24) | 1.08 (0.71–1.65) | ||||
| Polpulaire (47)† | 164 | 183 | 0.45 (0.29–0.71) | 0.90 (0.37–2.22) | ||||
| Stenvinkel (79)* | 30 | 145 | 1.64 (0.73–3.68) | 0.57 (0.07–4.81) | ||||
| Vasseur (54)* | 620 | 691 | 1.32 (1.05–1.66) | 1.30 (0.84–2.02) | ||||
| Vasseur (55)* | 231 | 270 | 1.48 (1.02–2.14) | 1.04 (0.44–2.46) | ||||
| Vozarova-De Courten (56)‡ | 510 | 429 | 0.59 (0.44–0.81) | 1.14 (0.78–1.68) | ||||
| C/G vs. G/G | 3,671 | 9,225 | 0.94 (0.75–1.18) | 0.60 | <0.0001 | 0.80 | ||
| C/C vs. G/G | 1.03 (0.87–1.22) | 0.79 | 0.84 | 0.04 | ||||
| g.+45T→G | T/G vs. T/T | G/G vs. T/T | ||||||
| Fumeron (36)* | 177 | 4,525 | 1.02 (0.71–1.44) | 0.16 (0.01–2.66) | ||||
| Gibson (37)* | 740 | 915 | 0.94 (0.75–1.17) | 0.89 (0.44–1.80) | ||||
| Gonzales-Sanchez (38)* | 61 | 530 | 1.43 (0.82–2.48) | 1.10 (0.24–4.93) | ||||
| Hara (34)† | 384 | 480 | 1.41 (1.06–1.88) | 1.70 (1.09–2.65) | ||||
| Hu (40)* | 642 | 995 | 0.90 (0.69–1.15) | 0.88 (0.35–2.26) | ||||
| Lee (43)† | 493 | 427 | 0.89 (0.68–1.17) | 0.69 (0.43–1.10) | ||||
| Menzaghi (45)* | 310 | 304 | 0.74 (0.50–1.09) | 0.71 (0.26–1.93) | ||||
| Polpulaire (47)† | 164 | 183 | 1.03 (0.66–1.61) | 1.54 (0.74–3.21) | ||||
| Stenvinkel (79)* | 26 | 145 | 1.60 (0.63–4.06) | 0.45 (0.02–8.50) | ||||
| Ukkola (53)* | 258 | 283 | 0.96 (0.54–1.72) | 0.22 (0.01–4.54) | ||||
| Vasseur (54)* | 582 | 680 | 1.05 (0.81–1.37) | 0.78 (0.41–1.49) | ||||
| Vasseur (55)* | 231 | 270 | 0.68 (0.44–1.03) | 0.61 (0.24–1.59) | ||||
| Vozarova-De Courten (56)‡ | 603 | 425 | 1.12 (0.80–1.56) | 0.48 (0.08–2.87) | ||||
| T/G vs. T/T | 4,671 | 10,162 | 0.99 (0.90–1.09) | 0.86 | 0.18 | 0.92 | ||
| G/G vs. T/T | 0.91 (0.68–1.23) | 0.54 | 0.25 | <0.001 | ||||
| g.+276G→T | G/T vs. G/G | T/T vs. G/G | ||||||
| Fumeron (36)* | 176 | 4,497 | 0.90 (0.65–1.24) | 1.23 (0.70–2.14) | ||||
| Gibson (37)* | 701 | 893 | 0.90 (0.73–1.11) | 0.80 (0.55–1.17) | ||||
| Gonzales-Sanchez (38)* | 61 | 530 | 1.50 (0.86–2.62) | 1.39 (0.50–3.85) | ||||
| Hara (34)† | 384 | 480 | 0.74 (0.56–0.98) | 0.46 (0.26–0.83) | ||||
| Hu (40)* | 642 | 995 | 1.08 (0.88–1.33) | 1.20 (0.82–1.75) | ||||
| Lee (43)† | 493 | 427 | 1.39 (1.06–1.82) | 1.09 (0.66–1.79) | ||||
| Menzaghi (45)* | 310 | 304 | 1.07 (0.77–1.50) | 1.05 (0.59–1.86) | ||||
| Polpulaire (47)† | 164 | 177 | 0.62 (0.39–0.99) | 1.11 (0.55–2.22) | ||||
| Stenvinkel (79)* | 30 | 145 | 0.63 (0.26–1.53) | 2.02 (0.61–6.62) | ||||
| Ukkola (53)* | 255 | 283 | 0.90 (0.62–1.29) | 1.07 (0.63–1.82) | ||||
| Vasseur (54)* | 577 | 681 | 1.11 (0.87–1.41) | 0.83 (0.56–1.21) | ||||
| Vasseur (55)* | 209 | 248 | 1.30 (0.88–1.93) | 1.36 (0.72–2.57) | ||||
| Vozarova-De Courten (56)‡ | 570 | 433 | 0.73 (0.55–0.95) | 0.73 (0.41–1.30) | ||||
| Yoshioka (57)† | 346 | 98 | 0.76 (0.48–1.22) | 1.07(0.46–2.49) | ||||
| G/T vs. G/G | 4,918 | 10,191 | 0.98 (0.86–1.10) | 0.42 | 0.008 | 0.64 | ||
| T/T vs. G/G | 0.95 (0.81–1.12) | 0.99 | 0.35 | 0.32 |
| Marker . | Study (ref.) . | Type 2 diabetic subjects (n) . | Control subjects (n) . | OR (95% CI) . | OR (95% CI) . | P . | P (hetero-geneity) . | P (publica-tion bias) . |
|---|---|---|---|---|---|---|---|---|
| g.−11391G→A | G/A vs. G/G | A/A vs. G/G | ||||||
| Fumeron (36)* | 177 | 4,510 | 0.95 (0.63–1.42) | 0.58 (0.08–4.28) | ||||
| Hara (34)† | 384 | 480 | 0.82 (0.44–1.52) | 1.24 (0.02–62.48) | ||||
| Gibson (37)* | 775 | 944 | 1.22 (0.95–1.57) | 1.45 (0.52–4.01) | ||||
| Stenvinkel (79)* | 30 | 145 | 1.59 (0.44–5.72) | 0.53 (0.03–10.16) | ||||
| Vasseur (54)* | 620 | 690 | 1.21 (0.91–1.62) | 2.08 (0.69–6.26) | ||||
| Vasseur (55)* | 231 | 270 | 1.22 (0.95–1.57) | 1.42 (0.38–5.36) | ||||
| G/A vs. G/G | 2,217 | 7,039 | 1.10 (0.94–1.28) | 0.23 | 0.48 | 0.31 | ||
| A/A vs. G/G | 1.41 (0.78–2.58) | 0.26 | 0.89 | 0.08 | ||||
| g.−11377C→G | C/G vs. C/C | G/G vs. C/C | ||||||
| Fumeron (36)* | 175 | 4,502 | 1.10 (0.80–1.51) | 0.68 (0.34–1.35) | ||||
| Gibson (37)* | 812 | 1,044 | 1.02 (0.84–1.24) | 1.05 (0.73–1.51) | ||||
| Gu (39)* | 103 | 486 | 0.78 (0.49–1.24) | 0.88 (0.43–1.80) | ||||
| Hara (34)† | 384 | 480 | 0.81 (0.61–1.08) | 0.74 (0.43–1.27) | ||||
| Hu (40)* | 642 | 995 | 1.00 (0.82–1.24) | 1.08 (0.71–1.65) | ||||
| Polpulaire (47)† | 164 | 183 | 0.45 (0.29–0.71) | 0.90 (0.37–2.22) | ||||
| Stenvinkel (79)* | 30 | 145 | 1.64 (0.73–3.68) | 0.57 (0.07–4.81) | ||||
| Vasseur (54)* | 620 | 691 | 1.32 (1.05–1.66) | 1.30 (0.84–2.02) | ||||
| Vasseur (55)* | 231 | 270 | 1.48 (1.02–2.14) | 1.04 (0.44–2.46) | ||||
| Vozarova-De Courten (56)‡ | 510 | 429 | 0.59 (0.44–0.81) | 1.14 (0.78–1.68) | ||||
| C/G vs. G/G | 3,671 | 9,225 | 0.94 (0.75–1.18) | 0.60 | <0.0001 | 0.80 | ||
| C/C vs. G/G | 1.03 (0.87–1.22) | 0.79 | 0.84 | 0.04 | ||||
| g.+45T→G | T/G vs. T/T | G/G vs. T/T | ||||||
| Fumeron (36)* | 177 | 4,525 | 1.02 (0.71–1.44) | 0.16 (0.01–2.66) | ||||
| Gibson (37)* | 740 | 915 | 0.94 (0.75–1.17) | 0.89 (0.44–1.80) | ||||
| Gonzales-Sanchez (38)* | 61 | 530 | 1.43 (0.82–2.48) | 1.10 (0.24–4.93) | ||||
| Hara (34)† | 384 | 480 | 1.41 (1.06–1.88) | 1.70 (1.09–2.65) | ||||
| Hu (40)* | 642 | 995 | 0.90 (0.69–1.15) | 0.88 (0.35–2.26) | ||||
| Lee (43)† | 493 | 427 | 0.89 (0.68–1.17) | 0.69 (0.43–1.10) | ||||
| Menzaghi (45)* | 310 | 304 | 0.74 (0.50–1.09) | 0.71 (0.26–1.93) | ||||
| Polpulaire (47)† | 164 | 183 | 1.03 (0.66–1.61) | 1.54 (0.74–3.21) | ||||
| Stenvinkel (79)* | 26 | 145 | 1.60 (0.63–4.06) | 0.45 (0.02–8.50) | ||||
| Ukkola (53)* | 258 | 283 | 0.96 (0.54–1.72) | 0.22 (0.01–4.54) | ||||
| Vasseur (54)* | 582 | 680 | 1.05 (0.81–1.37) | 0.78 (0.41–1.49) | ||||
| Vasseur (55)* | 231 | 270 | 0.68 (0.44–1.03) | 0.61 (0.24–1.59) | ||||
| Vozarova-De Courten (56)‡ | 603 | 425 | 1.12 (0.80–1.56) | 0.48 (0.08–2.87) | ||||
| T/G vs. T/T | 4,671 | 10,162 | 0.99 (0.90–1.09) | 0.86 | 0.18 | 0.92 | ||
| G/G vs. T/T | 0.91 (0.68–1.23) | 0.54 | 0.25 | <0.001 | ||||
| g.+276G→T | G/T vs. G/G | T/T vs. G/G | ||||||
| Fumeron (36)* | 176 | 4,497 | 0.90 (0.65–1.24) | 1.23 (0.70–2.14) | ||||
| Gibson (37)* | 701 | 893 | 0.90 (0.73–1.11) | 0.80 (0.55–1.17) | ||||
| Gonzales-Sanchez (38)* | 61 | 530 | 1.50 (0.86–2.62) | 1.39 (0.50–3.85) | ||||
| Hara (34)† | 384 | 480 | 0.74 (0.56–0.98) | 0.46 (0.26–0.83) | ||||
| Hu (40)* | 642 | 995 | 1.08 (0.88–1.33) | 1.20 (0.82–1.75) | ||||
| Lee (43)† | 493 | 427 | 1.39 (1.06–1.82) | 1.09 (0.66–1.79) | ||||
| Menzaghi (45)* | 310 | 304 | 1.07 (0.77–1.50) | 1.05 (0.59–1.86) | ||||
| Polpulaire (47)† | 164 | 177 | 0.62 (0.39–0.99) | 1.11 (0.55–2.22) | ||||
| Stenvinkel (79)* | 30 | 145 | 0.63 (0.26–1.53) | 2.02 (0.61–6.62) | ||||
| Ukkola (53)* | 255 | 283 | 0.90 (0.62–1.29) | 1.07 (0.63–1.82) | ||||
| Vasseur (54)* | 577 | 681 | 1.11 (0.87–1.41) | 0.83 (0.56–1.21) | ||||
| Vasseur (55)* | 209 | 248 | 1.30 (0.88–1.93) | 1.36 (0.72–2.57) | ||||
| Vozarova-De Courten (56)‡ | 570 | 433 | 0.73 (0.55–0.95) | 0.73 (0.41–1.30) | ||||
| Yoshioka (57)† | 346 | 98 | 0.76 (0.48–1.22) | 1.07(0.46–2.49) | ||||
| G/T vs. G/G | 4,918 | 10,191 | 0.98 (0.86–1.10) | 0.42 | 0.008 | 0.64 | ||
| T/T vs. G/G | 0.95 (0.81–1.12) | 0.99 | 0.35 | 0.32 |
Race/ethnicity:
Caucasian,
Asian,
Pima Indian.