ARHGEF11 SNPs significantly associated with type 2 diabetes and type 2 diabetes/IGT in the Amish
| SNP ID . | NCBI location . | SNP type . | Minor allele . | Minor allele frequency . | Location (SNP type) . | T2D vs. NGT . | . | T2D/IGT vs. NGT . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | P . | OR (95% CI) . | P . | OR (95% CI) . | ||
| RS3187878 | 153717717 | A/G | G | 0.19 | Exon 41 (3′ UTR) | 0.09 | 1.52 (0.94–2.47) | 0.01 | 1.61 (1.09–2.38) | ||
| RS6676 | 153717891 | C/T | T | 0.20 | Exon 41 (3′ UTR) | 0.21 | 1.35 (0.14–12.5) | 0.02 | 1.57 (1.06–2.32) | ||
| RS2275198 | 153719954 | A/G | A | 0.19 | Intron 39 | 0.28 | 1.31 (0.79–2.16) | 0.03 | 1.54 (1.03–2.30) | ||
| RS945508 | 153720154 | T/C | T | 0.47 | Exon 39 (R1467H) | 0.04 | 0.66 (0.44–0.98) | 0.17 | 0.81 (0.59–1.10) | ||
| RS3818807 | 153722376 | A/T | T | 0.20 | Intron37 | 0.22 | 1.35 (0.17–11.0) | 0.02 | 1.56 (1.06–2.31) | ||
| RS2275199 | 153722768 | C/T | T | 0.20 | Exon 36 (N1207N) | 0.15 | 1.44 (0.87–2.37) | 0.01 | 1.69 (1.15–2.50) | ||
| RS2275201 | 153728111 | C/T | T | 0.20 | Intron 29 | 0.18 | 1.39 (0.85–2.27) | 0.02 | 1.60 (1.07–2.38) | ||
| RS2275202 | 153734293 | C/T | T | 0.05 | Intron 22 | 0.12 | 0.47 (0.18–1.25) | 0.005 | 0.33 (0.15–0.75) | ||
| RS2275204 | 153738508 | A/G | G | 0.19 | Intron 20 | 0.26 | 1.34 (1.03–1.74) | 0.04 | 1.52 (1.02–2.28) | ||
| RS1572409 | 153741849 | A/T | T | 0.20 | Intron 17 | 0.12 | 1.34 (0.83–2.17) | 0.03 | 1.54 (1.04–2.30) | ||
| RS12136088 | 153754485 | G/T | T | 0.23 | Intron 8 | 0.002 | 1.56 (0.97–2.52) | 0.003 | 1.77 (1.21–2.58) | ||
| RS1336147 | 153757272 | A/G | G | 0.24 | Intron 8 | 0.09 | 1.48 (0.94–2.34) | 0.009 | 1.63 (1.13–2.37) | ||
| RS1006168 | 153759971 | A/C | C | 0.24 | Intron 6 | 0.03 | 1.67 (1.05–2.66) | 0.01 | 1.63 (1.13–2.37) | ||
| RS12141806 | 153761026 | A/T | T | 0.23 | Intron 6 | 0.05 | 1.60 (1.01–2.54) | 0.007 | 1.68 (1.14–2.46) | ||
| RS1007604 | 153761953 | G/T | T | 0.23 | Intron 5 | 0.15 | 1.39 (0.89–2.17) | 0.02 | 1.54 (1.08–2.22) | ||
| RS1572416 | 153765127 | A/C | A | 0.24 | Intron 3 | 0.08 | 1.49 (0.93–2.38) | 0.009 | 1.64 (1.14–2.38) | ||
| RS6427339 | 153767340 | C/T | T | 0.42 | Intron 2 | 0.02 | 1.66 (1.08–2.55) | 0.006 | 1.60 (1.14–2.25) | ||
| RS6427340 | 153767457 | C/T | C | 0.41 | Intron 2 | 0.005 | 1.82 (1.20–2.70) | 0.0008 | 1.79 (1.27–2.50) | ||
| RS7541702 | 153767506 | C/T | C | 0.23 | Intron 2 | 0.06 | 1.56 (0.98–2.50) | 0.009 | 1.67 (1.12–2.44) | ||
| RS1572414 | 153776947 | C/T | C | 0.24 | Intron 1 | 0.08 | 1.49 (0.93–2.38) | 0.009 | 1.64 (1.14–2.38) | ||
| RS884891 | 153782676 | C/T | C | 0.24 | Intron 1 | 0.09 | 1.47 (0.93–2.38) | 0.009 | 1.61 (1.12–2.33) | ||
| RS822581 | 153789298 | A/G | G | 0.24 | Intron 1 | 0.08 | 1.49 (0.94–2.34) | 0.009 | 1.63 (1.13–2.37) | ||
| RS703152 | 153790978 | A/G | A | 0.24 | Intron 1 | 0.09 | 1.48 (0.82–2.67) | 0.01 | 1.61 (1.12–2.32) | ||
| RS822576 | 153804644 | C/T | C | 0.47 | Intron 1 | 0.06 | 1.45 (0.01–100) | 0.01 | 1.47 (1.08–2.00) | ||
| RS1336146 | 153815516 | C/T | T | 0.47 | Intron 1 | 0.06 | 1.43 (0.97–2.10) | 0.02 | 1.46 (1.07–1.99) | ||
| RS822570 | 153820575 | A/G | G | 0.47 | Intron 1 | 0.06 | 1.44 (0.02–127) | 0.02 | 1.46 (1.07–1.99) | ||
| RS822572 | 153827775 | A/G | G | 0.47 | Exon 1 (5′ UTR) | 0.08 | 1.40 (0.96–2.06) | 0.02 | 1.45 (1.07–1.97) | ||
| RS861086 | 153829497 | A/G | G | 0.007 | 5′ Flank | 0.113 | 12.5 (11.1–16.7) | 0.01 | 12.5 (10.0–14.3) | ||
| RS822585 | 153830278 | A/T | A | 0.41 | 5′ Flank | 0.01 | 1.69 (0.36–8.33) | 0.01 | 1.52 (1.09–2.08) | ||
| RS1750810 | 153850563 | C/G | C | 0.47 | 5′ Flank | 0.07 | 1.43 (0.005–500) | 0.01 | 1.47 (1.09–2.00) | ||
| SNP ID . | NCBI location . | SNP type . | Minor allele . | Minor allele frequency . | Location (SNP type) . | T2D vs. NGT . | . | T2D/IGT vs. NGT . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | P . | OR (95% CI) . | P . | OR (95% CI) . | ||
| RS3187878 | 153717717 | A/G | G | 0.19 | Exon 41 (3′ UTR) | 0.09 | 1.52 (0.94–2.47) | 0.01 | 1.61 (1.09–2.38) | ||
| RS6676 | 153717891 | C/T | T | 0.20 | Exon 41 (3′ UTR) | 0.21 | 1.35 (0.14–12.5) | 0.02 | 1.57 (1.06–2.32) | ||
| RS2275198 | 153719954 | A/G | A | 0.19 | Intron 39 | 0.28 | 1.31 (0.79–2.16) | 0.03 | 1.54 (1.03–2.30) | ||
| RS945508 | 153720154 | T/C | T | 0.47 | Exon 39 (R1467H) | 0.04 | 0.66 (0.44–0.98) | 0.17 | 0.81 (0.59–1.10) | ||
| RS3818807 | 153722376 | A/T | T | 0.20 | Intron37 | 0.22 | 1.35 (0.17–11.0) | 0.02 | 1.56 (1.06–2.31) | ||
| RS2275199 | 153722768 | C/T | T | 0.20 | Exon 36 (N1207N) | 0.15 | 1.44 (0.87–2.37) | 0.01 | 1.69 (1.15–2.50) | ||
| RS2275201 | 153728111 | C/T | T | 0.20 | Intron 29 | 0.18 | 1.39 (0.85–2.27) | 0.02 | 1.60 (1.07–2.38) | ||
| RS2275202 | 153734293 | C/T | T | 0.05 | Intron 22 | 0.12 | 0.47 (0.18–1.25) | 0.005 | 0.33 (0.15–0.75) | ||
| RS2275204 | 153738508 | A/G | G | 0.19 | Intron 20 | 0.26 | 1.34 (1.03–1.74) | 0.04 | 1.52 (1.02–2.28) | ||
| RS1572409 | 153741849 | A/T | T | 0.20 | Intron 17 | 0.12 | 1.34 (0.83–2.17) | 0.03 | 1.54 (1.04–2.30) | ||
| RS12136088 | 153754485 | G/T | T | 0.23 | Intron 8 | 0.002 | 1.56 (0.97–2.52) | 0.003 | 1.77 (1.21–2.58) | ||
| RS1336147 | 153757272 | A/G | G | 0.24 | Intron 8 | 0.09 | 1.48 (0.94–2.34) | 0.009 | 1.63 (1.13–2.37) | ||
| RS1006168 | 153759971 | A/C | C | 0.24 | Intron 6 | 0.03 | 1.67 (1.05–2.66) | 0.01 | 1.63 (1.13–2.37) | ||
| RS12141806 | 153761026 | A/T | T | 0.23 | Intron 6 | 0.05 | 1.60 (1.01–2.54) | 0.007 | 1.68 (1.14–2.46) | ||
| RS1007604 | 153761953 | G/T | T | 0.23 | Intron 5 | 0.15 | 1.39 (0.89–2.17) | 0.02 | 1.54 (1.08–2.22) | ||
| RS1572416 | 153765127 | A/C | A | 0.24 | Intron 3 | 0.08 | 1.49 (0.93–2.38) | 0.009 | 1.64 (1.14–2.38) | ||
| RS6427339 | 153767340 | C/T | T | 0.42 | Intron 2 | 0.02 | 1.66 (1.08–2.55) | 0.006 | 1.60 (1.14–2.25) | ||
| RS6427340 | 153767457 | C/T | C | 0.41 | Intron 2 | 0.005 | 1.82 (1.20–2.70) | 0.0008 | 1.79 (1.27–2.50) | ||
| RS7541702 | 153767506 | C/T | C | 0.23 | Intron 2 | 0.06 | 1.56 (0.98–2.50) | 0.009 | 1.67 (1.12–2.44) | ||
| RS1572414 | 153776947 | C/T | C | 0.24 | Intron 1 | 0.08 | 1.49 (0.93–2.38) | 0.009 | 1.64 (1.14–2.38) | ||
| RS884891 | 153782676 | C/T | C | 0.24 | Intron 1 | 0.09 | 1.47 (0.93–2.38) | 0.009 | 1.61 (1.12–2.33) | ||
| RS822581 | 153789298 | A/G | G | 0.24 | Intron 1 | 0.08 | 1.49 (0.94–2.34) | 0.009 | 1.63 (1.13–2.37) | ||
| RS703152 | 153790978 | A/G | A | 0.24 | Intron 1 | 0.09 | 1.48 (0.82–2.67) | 0.01 | 1.61 (1.12–2.32) | ||
| RS822576 | 153804644 | C/T | C | 0.47 | Intron 1 | 0.06 | 1.45 (0.01–100) | 0.01 | 1.47 (1.08–2.00) | ||
| RS1336146 | 153815516 | C/T | T | 0.47 | Intron 1 | 0.06 | 1.43 (0.97–2.10) | 0.02 | 1.46 (1.07–1.99) | ||
| RS822570 | 153820575 | A/G | G | 0.47 | Intron 1 | 0.06 | 1.44 (0.02–127) | 0.02 | 1.46 (1.07–1.99) | ||
| RS822572 | 153827775 | A/G | G | 0.47 | Exon 1 (5′ UTR) | 0.08 | 1.40 (0.96–2.06) | 0.02 | 1.45 (1.07–1.97) | ||
| RS861086 | 153829497 | A/G | G | 0.007 | 5′ Flank | 0.113 | 12.5 (11.1–16.7) | 0.01 | 12.5 (10.0–14.3) | ||
| RS822585 | 153830278 | A/T | A | 0.41 | 5′ Flank | 0.01 | 1.69 (0.36–8.33) | 0.01 | 1.52 (1.09–2.08) | ||
| RS1750810 | 153850563 | C/G | C | 0.47 | 5′ Flank | 0.07 | 1.43 (0.005–500) | 0.01 | 1.47 (1.09–2.00) | ||
NCBI location is based on Build 35.1. OR > 1.00 denotes that the minor allele is the risk allele, while OR < 1.00 denotes that the major allele is the risk allele. T2D, type 2 diabetes; UTR, untranslated region.