American Diabetes Association

TABLE 2

Association analysis of ARHGEF11 haplotypes with type 2 diabetes and type 2 diabetes/IGT and glucose AUC during an oral glucose tolerance test

Haplotype	Haplotype frequency					T2D vs. NGT			T2D/IGT vs. NGT
Haplotype		T2D	IGT	NGT	Haploscore	P	Haploscore	P	Haploscore	P
AGAAGCTTA	0.71	0.67	0.79	−2.35	0.019	−3.71	0.0002	−3.20	0.001
TGAAGCTTA	0.008	0.011	0.003	0.84	0.40	1.36	0.18	0.54	0.59
ATAAGCTTA	0.004	0.026	0.003	0.15	0.88	1.74	0.082	1.69	0.091
ATGTTACCG	0.050	0.044	0.028	1.73	0.083	1.83	0.068	1.62	0.11
TTGTTACCG	0.22	0.25	0.17	1.55	0.12	2.56	0.010	2.52	0.012

Haplotype	Haplotype frequency					T2D vs. NGT			T2D/IGT vs. NGT
Haplotype		T2D	IGT	NGT	Haploscore	P	Haploscore	P	Haploscore	P
AGAAGCTTA	0.71	0.67	0.79	−2.35	0.019	−3.71	0.0002	−3.20	0.001
TGAAGCTTA	0.008	0.011	0.003	0.84	0.40	1.36	0.18	0.54	0.59
ATAAGCTTA	0.004	0.026	0.003	0.15	0.88	1.74	0.082	1.69	0.091
ATGTTACCG	0.050	0.044	0.028	1.73	0.083	1.83	0.068	1.62	0.11
TTGTTACCG	0.22	0.25	0.17	1.55	0.12	2.56	0.010	2.52	0.012

Haplotype frequencies were estimated with Haploscore for the nine positively associated ARHGEF11 SNPs by case-control analysis and transmissional disequilibrium test (RS1572409, RS12136088, RS1336147, RS12141806, RS1007604, RS1572416, RS1572414, RS884891, and RS822581). Global P value for test = 0.28, 0.006, and 0.008 for type 2 diabetes vs. NGT, type 2 diabetes/IGT vs. NGT, and glucose AUC, respectively. Bold face data denote statistical significance. T2D, type 2 diabetes.

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