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TABLE 1

Source of tissue samples used for analysis of CD68, CD163, CD3, and HLA-2 in diabetic and nondiabetic individuals

Patient no.Age (years)Sex (M/F)BMI (kg/m2)FPG (mmol/l)Source of pancreasReasonDiabetes therapy
Nondiabetic individuals         
 51 21 4.7 Operation Carcinoma N/A 
 63 N/A Operation Benign endocrine pancreas tumor N/A 
 63 23 4.4 Operation Carcinoma N/A 
 89 25 3.6 Necropsy Aorta dissection N/A 
 81 25 5.3 Necropsy Ischemic heart disease N/A 
 74 24 5.7 Necropsy Cardiac shock N/A 
 72 21 4.5 Necropsy Ischemic heart disease N/A 
    Mean  70  23.2 4.6    
Diabetic individuals         
 64 26 11.7 Operation Carcinoma Diet 
 66 29 7.3 Operation Benign endocrine pancreas tumor Insulin 
 10 63 33 15 Operation Carcinoma Diet 
 11 68 32 10.7 Operation Ectopic spleen, normal pancreas Diet 
 12 61 N/A 16 Organ donor Transplantation N/A 
 13 83 23 9.8 Necropsy Ischemic heart disease Diet 
 14 77 26 8.4 Necropsy Ventricular fibrillation Oral antidiabetes agent (metformin) 
 15 56 22 25 Necropsy Ischemic heart disease Diet 
 16 74 23 14.7 Necropsy Ischemic heart disease Oral antidiabetes agent (metformin) 
    Mean  68  26.8* 13.2*    
Patient no.Age (years)Sex (M/F)BMI (kg/m2)FPG (mmol/l)Source of pancreasReasonDiabetes therapy
Nondiabetic individuals         
 51 21 4.7 Operation Carcinoma N/A 
 63 N/A Operation Benign endocrine pancreas tumor N/A 
 63 23 4.4 Operation Carcinoma N/A 
 89 25 3.6 Necropsy Aorta dissection N/A 
 81 25 5.3 Necropsy Ischemic heart disease N/A 
 74 24 5.7 Necropsy Cardiac shock N/A 
 72 21 4.5 Necropsy Ischemic heart disease N/A 
    Mean  70  23.2 4.6    
Diabetic individuals         
 64 26 11.7 Operation Carcinoma Diet 
 66 29 7.3 Operation Benign endocrine pancreas tumor Insulin 
 10 63 33 15 Operation Carcinoma Diet 
 11 68 32 10.7 Operation Ectopic spleen, normal pancreas Diet 
 12 61 N/A 16 Organ donor Transplantation N/A 
 13 83 23 9.8 Necropsy Ischemic heart disease Diet 
 14 77 26 8.4 Necropsy Ventricular fibrillation Oral antidiabetes agent (metformin) 
 15 56 22 25 Necropsy Ischemic heart disease Diet 
 16 74 23 14.7 Necropsy Ischemic heart disease Oral antidiabetes agent (metformin) 
    Mean  68  26.8* 13.2*    

All tissue samples were obtained from the Department of Pathology, University Hospital of Zürich, Zürich, Switzerland. Patients with pancreatitis, lymphoma, and systemic infection and who were on immunosuppressive therapy were excluded from analysis.

*

P < 0.05 vs. nondiabetic patients. FPG, fasting plasma glucose; N/A, not available/not applicable.

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