Incidence of insulitis in pancreas after 50 μg anti-CD3 Ab
| Feeding . | IP . | Islets . | Normal islets . | Peri-insulitis . | Invasive insulitis . |
|---|---|---|---|---|---|
| PBS | STZ | 72 | 50 (69) | 15 (21) | 7 (10) |
| Control IgG | STZ | 88 | 62 (71) | 15 (17) | 11 (13) |
| Anti-CD3 Ab | STZ | 135 | 125 (93)** | 8 (6)** | 2 (2)* |
| None | None | 66 | 66 (100) | 0 (0) | 0 (0) |
| Feeding . | IP . | Islets . | Normal islets . | Peri-insulitis . | Invasive insulitis . |
|---|---|---|---|---|---|
| PBS | STZ | 72 | 50 (69) | 15 (21) | 7 (10) |
| Control IgG | STZ | 88 | 62 (71) | 15 (17) | 11 (13) |
| Anti-CD3 Ab | STZ | 135 | 125 (93)** | 8 (6)** | 2 (2)* |
| None | None | 66 | 66 (100) | 0 (0) | 0 (0) |
Data are n or n (%). Sections of pancreas from 6–8 mice/group (nontreated group; n = 4) on day 28 were scored for the presence of insulitis. Pooled insulitis score data were statistically analyzed by χ2 test.
P < 0.01 compared with the PBS group or the control IgG group. IP, intraperitoneal injection.