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TABLE 1

Characteristics of aAb+ donors

Case subjectAge (years)SexBMI (kg/m2)aAb titers
HLA DQA1*-DQB1* haplotype1/ haplotype2HLA risk
ICAGADAIA2-AIAA
Positivity for minimally two autoantibodies            
    1 59 Male 22 100 1,067.2 2.6 1.7 0501–0201/0501–0201 S 
    2 46 Female 21 50 213.5 54.6 0301–0302/0301–0302 S 
    3 44 Male 24 100 1,928.6 42.6 0301–0302/0501–0201 S 
    4 50 Female 21 50 567 02–0202/0501–0201 
    5 54 Male 30 25 163.9 01–0602/0301–0302 
    6 49 Male 28 25 3.6 01–0501/01–0501 
    7 39 Male 26 12 1.0 0501–0301/0501–0301 
Positivity for only one of the tested autoantibodies            
    n = 55 46 (26–60)* 33/22 25 (18–30)* n = 19 n = 27 n = 3 n = 6 NT  
Matched aAb controls          
    n = 62 46 (25–60)* 38/24 24 (18–31)* n = 0 n = 0 n = 0 n = 0 NT  
Case subjectAge (years)SexBMI (kg/m2)aAb titers
HLA DQA1*-DQB1* haplotype1/ haplotype2HLA risk
ICAGADAIA2-AIAA
Positivity for minimally two autoantibodies            
    1 59 Male 22 100 1,067.2 2.6 1.7 0501–0201/0501–0201 S 
    2 46 Female 21 50 213.5 54.6 0301–0302/0301–0302 S 
    3 44 Male 24 100 1,928.6 42.6 0301–0302/0501–0201 S 
    4 50 Female 21 50 567 02–0202/0501–0201 
    5 54 Male 30 25 163.9 01–0602/0301–0302 
    6 49 Male 28 25 3.6 01–0501/01–0501 
    7 39 Male 26 12 1.0 0501–0301/0501–0301 
Positivity for only one of the tested autoantibodies            
    n = 55 46 (26–60)* 33/22 25 (18–30)* n = 19 n = 27 n = 3 n = 6 NT  
Matched aAb controls          
    n = 62 46 (25–60)* 38/24 24 (18–31)* n = 0 n = 0 n = 0 n = 0 NT  

aAb titers are expressed as JDFU (ICA) or as percentage of tracer binding (GADA, IA2-A, and IAA); <, below cutoff value.

*

Median (range). HLA risk haplotypes in bold. N, neutral HLA-DQ genotype; NT, not tested; P, protective HLA-DQ genotype; S, susceptible HLA-DQ genotype.

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