American Diabetes Association

TABLE 1

Characteristics of aAb⁺ donors

Case subject	Age (years)	Sex	BMI (kg/m²)	aAb titers							HLA DQA1^-DQB1^ haplotype1/ haplotype2	HLA risk
Case subject	Age (years)	Sex	BMI (kg/m²)					ICA	GADA	IA2-A	HLA DQA1^-DQB1^ haplotype1/ haplotype2	HLA risk	IAA
Positivity for minimally two autoantibodies
1	59	Male	22	100	1,067.2	2.6	1.7	0501–0201/0501–0201	S
2	46	Female	21	50	213.5	54.6	<	0301–0302/0301–0302	S
3	44	Male	24	100	1,928.6	42.6	<	0301–0302/0501–0201	S
4	50	Female	21	50	567	<	<	02–0202/0501–0201	P
5	54	Male	30	25	163.9	<	<	01–0602/0301–0302	P
6	49	Male	28	25	3.6	<	<	01–0501/01–0501	N
7	39	Male	26	12	<	1.0	<	0501–0301/0501–0301	P
Positivity for only one of the tested autoantibodies
n = 55	46 (26–60)^*	33/22	25 (18–30)^*	n = 19	n = 27	n = 3	n = 6	NT
Matched aAb⁻ controls
n = 62	46 (25–60)^*	38/24	24 (18–31)^*	n = 0	n = 0	n = 0	n = 0	NT

Case subject	Age (years)	Sex	BMI (kg/m²)	aAb titers							HLA DQA1^-DQB1^ haplotype1/ haplotype2	HLA risk
Case subject	Age (years)	Sex	BMI (kg/m²)					ICA	GADA	IA2-A	HLA DQA1^-DQB1^ haplotype1/ haplotype2	HLA risk	IAA
Positivity for minimally two autoantibodies
1	59	Male	22	100	1,067.2	2.6	1.7	0501–0201/0501–0201	S
2	46	Female	21	50	213.5	54.6	<	0301–0302/0301–0302	S
3	44	Male	24	100	1,928.6	42.6	<	0301–0302/0501–0201	S
4	50	Female	21	50	567	<	<	02–0202/0501–0201	P
5	54	Male	30	25	163.9	<	<	01–0602/0301–0302	P
6	49	Male	28	25	3.6	<	<	01–0501/01–0501	N
7	39	Male	26	12	<	1.0	<	0501–0301/0501–0301	P
Positivity for only one of the tested autoantibodies
n = 55	46 (26–60)^*	33/22	25 (18–30)^*	n = 19	n = 27	n = 3	n = 6	NT
Matched aAb⁻ controls
n = 62	46 (25–60)^*	38/24	24 (18–31)^*	n = 0	n = 0	n = 0	n = 0	NT

aAb titers are expressed as JDFU (ICA) or as percentage of tracer binding (GADA, IA2-A, and IAA); <, below cutoff value.

Median (range). HLA risk haplotypes in bold. N, neutral HLA-DQ genotype; NT, not tested; P, protective HLA-DQ genotype; S, susceptible HLA-DQ genotype.

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