TABLE 1

Factors . | . | Obgen obese children (n = 358). | . | Saint Vincent obese children (n = 397). | . | Lille obese children (n = 350). | . | Napoli obese children (n = 607). | . | Ile-de-France obese children (n = 164). | . | Pooled five cohorts (n = 1,876). | . | . | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|

. | . | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value^{†}
. | P value^{‡}
. | |||||||

BMI | 0.07 ± 0.03 | 5 × 10^{−4} | 0.13 ± 0.04 | 2 × 10^{−4} | 0.17 ± 0.06 | 5 × 10^{−3} | 0.17 ± 0.05 | 8 × 10^{−4} | 0.09 ± 0.05 | 0.01 | 0.10 ± 0.03 | 1.2 × 10^{−14} | 8 × 10^{−14} | ||||||||

p110β | T/T | 2.15 ± 0.38 | 3.3 × 10^{4} | 2.55 ± 0.35 | 1.7 × 10^{−12} | 1.30 ± 0.48 | 7 × 10^{3} | 1.54 ± 0.35 | 1 × 10^{−5} | 1.46 ± 0.38 | 2 × 10^{−4} | 2.03 ± 0.16 | 3.2 × 10^{−15} | 0.0000 | |||||||

C/T | 0.79 ± 0.30 | 9 × 10^{−4} | 1.47 ± 0.33 | 1.0 × 10^{−5} | 0.38 ± 0.44 | 0.15 | 0.70 ± 0.30 | 2 × 10^{−3} | 1.13 ± 0.35 | 1.5 × 10^{−3} | 1.12 ± 0.14 | 3.7 × 10^{−8} | 0.0000 | ||||||||

C/C | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||

p110β × BMI | T/T | 0.29 ± 0.05 | 6 × 10^{9} | 0.38 ± 0.05 | 1.9 × 10^{−12} | 0.19 ± 0.08 | 0.01 | 0.25 ± 0.07 | 6 × 10^{−1} | 0.14 ± 0.07 | 0.048 | 0.30 ± 0.30 | 2.1 × 10^{−8} | 0.0000 | |||||||

C/T | 0.14 ± 0.04 | 8 × 10^{4} | 0.17 ± 0.04 | 2 × 10^{−4} | 0.10 ± 0.07 | 0.2 | 0.07 ± 0.06 | 0.2 | 0.12 ± 0.06 | 0.035 | 0.17 ± 0.02 | 2 × 10^{−6} | 0.0000 | ||||||||

C/C | 0 | 0 | 0 | 0 | 0 | 0 |

Factors . | . | Obgen obese children (n = 358). | . | Saint Vincent obese children (n = 397). | . | Lille obese children (n = 350). | . | Napoli obese children (n = 607). | . | Ile-de-France obese children (n = 164). | . | Pooled five cohorts (n = 1,876). | . | . | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|

. | . | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value
. | Regression coefficients^{*}
. | P value^{†}
. | P value^{‡}
. | |||||||

BMI | 0.07 ± 0.03 | 5 × 10^{−4} | 0.13 ± 0.04 | 2 × 10^{−4} | 0.17 ± 0.06 | 5 × 10^{−3} | 0.17 ± 0.05 | 8 × 10^{−4} | 0.09 ± 0.05 | 0.01 | 0.10 ± 0.03 | 1.2 × 10^{−14} | 8 × 10^{−14} | ||||||||

p110β | T/T | 2.15 ± 0.38 | 3.3 × 10^{4} | 2.55 ± 0.35 | 1.7 × 10^{−12} | 1.30 ± 0.48 | 7 × 10^{3} | 1.54 ± 0.35 | 1 × 10^{−5} | 1.46 ± 0.38 | 2 × 10^{−4} | 2.03 ± 0.16 | 3.2 × 10^{−15} | 0.0000 | |||||||

C/T | 0.79 ± 0.30 | 9 × 10^{−4} | 1.47 ± 0.33 | 1.0 × 10^{−5} | 0.38 ± 0.44 | 0.15 | 0.70 ± 0.30 | 2 × 10^{−3} | 1.13 ± 0.35 | 1.5 × 10^{−3} | 1.12 ± 0.14 | 3.7 × 10^{−8} | 0.0000 | ||||||||

C/C | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||

p110β × BMI | T/T | 0.29 ± 0.05 | 6 × 10^{9} | 0.38 ± 0.05 | 1.9 × 10^{−12} | 0.19 ± 0.08 | 0.01 | 0.25 ± 0.07 | 6 × 10^{−1} | 0.14 ± 0.07 | 0.048 | 0.30 ± 0.30 | 2.1 × 10^{−8} | 0.0000 | |||||||

C/T | 0.14 ± 0.04 | 8 × 10^{4} | 0.17 ± 0.04 | 2 × 10^{−4} | 0.10 ± 0.07 | 0.2 | 0.07 ± 0.06 | 0.2 | 0.12 ± 0.06 | 0.035 | 0.17 ± 0.02 | 2 × 10^{−6} | 0.0000 | ||||||||

C/C | 0 | 0 | 0 | 0 | 0 | 0 |

Data are means±SE. Estimates of regression coefficients were calculated for a BMI of 35 kg/m^{2}. This modeling shows the expected influence of BMI and the consistent influence of the −359 genotype on insulin resistance. It also shows a significant modification of the HOMA-BMI relationship by the −359 genotype.

*

Estimate of regression coefficient, mean±SE.

†

Overall significance for the pooled 5 obese cohorts.

‡

Using a mixed-effects model was used to account for potential center effects when pooling the 5 cohorts together. The value of *P* < 0.0000 is the lowest possible generated by the use of the latter model.

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.