Characteristics of the 11 common SNPs neighboring the functional −359 C/T variant over 80 kb of the p110β gene region
| Single nucleotide polymorphism . | Gene . | MAF . | Significance of association with HOMA (P value) . | Physical position . | Distance from −359 C/T (bp) . | HWE (P value) . |
|---|---|---|---|---|---|---|
| rs1679168 | FAM62 | 0.26 | 0.99 | 139674890 | 286352 | 0.847 |
| rs1618357 | FAM62 | 0.41 | 0.65 | 139677133 | 284109 | 0.490 |
| rs6439809 | Cep70 | 0.48 | 0.30 | 139709731 | 251511 | 0.878 |
| rs9855074 | Cep70 | 0.23 | 0.39 | 139727626 | 233616 | 0.191 |
| rs12636246 | FAIM | 0.38 | 0.98 | 139829284 | 131958 | 0.261 |
| rs601032 | FAIM | 0.23 | 0.39 | 139832030 | 129212 | 0.823 |
| rs600590* | FAIM | 0.49 | 5.10−5 | 139832105 | 129137 | 1 |
| rs9878820 | p110β | 0.37 | 0.27 | 139868113 | 93129 | 0.606 |
| rs693293 | p110β | 0.11 | 0.88 | 139891874 | 69368 | 0.673 |
| rs361080* | p110β | 0.50 | 1.3 × 10−6 | 139900687 | 60555 | 0.323 |
| rs361072 (−359 C/T) | p110β | 0.49 | 3.3 × 10−8 | 139961242 | 0 | 0.99 |
| rs11716652 | — | 0.11 | 0.23 | 140048087 | 86845 | 0.144 |
| Single nucleotide polymorphism . | Gene . | MAF . | Significance of association with HOMA (P value) . | Physical position . | Distance from −359 C/T (bp) . | HWE (P value) . |
|---|---|---|---|---|---|---|
| rs1679168 | FAM62 | 0.26 | 0.99 | 139674890 | 286352 | 0.847 |
| rs1618357 | FAM62 | 0.41 | 0.65 | 139677133 | 284109 | 0.490 |
| rs6439809 | Cep70 | 0.48 | 0.30 | 139709731 | 251511 | 0.878 |
| rs9855074 | Cep70 | 0.23 | 0.39 | 139727626 | 233616 | 0.191 |
| rs12636246 | FAIM | 0.38 | 0.98 | 139829284 | 131958 | 0.261 |
| rs601032 | FAIM | 0.23 | 0.39 | 139832030 | 129212 | 0.823 |
| rs600590* | FAIM | 0.49 | 5.10−5 | 139832105 | 129137 | 1 |
| rs9878820 | p110β | 0.37 | 0.27 | 139868113 | 93129 | 0.606 |
| rs693293 | p110β | 0.11 | 0.88 | 139891874 | 69368 | 0.673 |
| rs361080* | p110β | 0.50 | 1.3 × 10−6 | 139900687 | 60555 | 0.323 |
| rs361072 (−359 C/T) | p110β | 0.49 | 3.3 × 10−8 | 139961242 | 0 | 0.99 |
| rs11716652 | — | 0.11 | 0.23 | 140048087 | 86845 | 0.144 |
Bold type, −359 C/T variant. Association of each SNP with HOMA is described using the general linear model. *Two SNPs (rs600590 and rs361080) were found to be in near complete linkage disequilibrium (D/Dmas > 0.985) with the functional −359 SNP, and thus both showed association with HOMA. MAF, minor allele frequency.