Main characteristics of rs361072 genotypic groups in the five pooled cohorts of obese children and the two pooled cohorts of nonobese children
| . | Total obese children* (n = 1,876) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | TT . | CT . | CC . | P value . | |||
| n | 468 | 930 | 478 | ||||
| Percent female | 56 | 56 | 54 | ||||
| Age (years) | 11.9 ± 0.1 | 12.0 ± 0.1 | 12.1 ± 0.1 | 0.68 | |||
| BMI (kg/m2) | 32.3 ± 0.3 | 31.9 ± 0.2 | 32.2 ± 0.3 | 0.52 | |||
| Fasting insulin (μU/ml) | 20.9 ± 0.7 | 18.5 ± 0.4 | 16.1 ± 0.4 | 1.6 10−5 | |||
| Fasting glucose (mg/dl) | 86 ± 0.5 | 84 ± 0.3 | 84 ± 0.4 | 0.02 | |||
| HOMA-IR | 4.5 ± 0.2 | 3.9 ± 0.1 | 3.3 ± 0.1 | 4.5 10−6 | |||
| . | Total obese children* (n = 1,876) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | TT . | CT . | CC . | P value . | |||
| n | 468 | 930 | 478 | ||||
| Percent female | 56 | 56 | 54 | ||||
| Age (years) | 11.9 ± 0.1 | 12.0 ± 0.1 | 12.1 ± 0.1 | 0.68 | |||
| BMI (kg/m2) | 32.3 ± 0.3 | 31.9 ± 0.2 | 32.2 ± 0.3 | 0.52 | |||
| Fasting insulin (μU/ml) | 20.9 ± 0.7 | 18.5 ± 0.4 | 16.1 ± 0.4 | 1.6 10−5 | |||
| Fasting glucose (mg/dl) | 86 ± 0.5 | 84 ± 0.3 | 84 ± 0.4 | 0.02 | |||
| HOMA-IR | 4.5 ± 0.2 | 3.9 ± 0.1 | 3.3 ± 0.1 | 4.5 10−6 | |||
| . | Nonobese children† (n = 1,490) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | TT . | CT . | CC . | P value . | |||
| n | 355 | 746 | 389 | ||||
| Percent female | 61 | 62 | 66 | ||||
| Age (years) | 12.1 ± 0.1 | 11.8 ± 0.1 | 11.7 ± 0.1 | 0.21 | |||
| BMI (kg/m2) | 18.2 ± 0.1 | 18.3 ± 0.1 | 18.1 ± 0.1 | 0.58 | |||
| Fasting insulin (μU/ml) | 9.2 ± 0.2 | 8.8 ± 0.1 | 8.7 ± 0.1 | 0.04 | |||
| Fasting glucose (mg/dl) | 84 ± 0.2 | 83 ± 0.2 | 83 ± 0.2 | 0.62 | |||
| HOMA-IR | 2.0 ± 0.04 | 1.9 ± 0.02 | 1.9 ± 0.03 | 0.04 | |||
| . | Nonobese children† (n = 1,490) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | TT . | CT . | CC . | P value . | |||
| n | 355 | 746 | 389 | ||||
| Percent female | 61 | 62 | 66 | ||||
| Age (years) | 12.1 ± 0.1 | 11.8 ± 0.1 | 11.7 ± 0.1 | 0.21 | |||
| BMI (kg/m2) | 18.2 ± 0.1 | 18.3 ± 0.1 | 18.1 ± 0.1 | 0.58 | |||
| Fasting insulin (μU/ml) | 9.2 ± 0.2 | 8.8 ± 0.1 | 8.7 ± 0.1 | 0.04 | |||
| Fasting glucose (mg/dl) | 84 ± 0.2 | 83 ± 0.2 | 83 ± 0.2 | 0.62 | |||
| HOMA-IR | 2.0 ± 0.04 | 1.9 ± 0.02 | 1.9 ± 0.03 | 0.04 | |||
Data are means±SE. P values refer to analysis of variance between genotype groups after log transformation of insulin, glucose, and HOMA-IR. For clarity, real values of these parameters are displayed.
Pooled from Obgen, Saint Vincent, Lille, Napoli, and Ile-de-France cohorts. †Pooled from Leangen and Growthgen cohorts. To convert values for insulin to picomoles per liter, multiply by 6; to convert values for glucose to millimoles per liter, multiply by 0.055.