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TABLE 1

Plasma measurements of lipids and adipokines in wild-type and α4(Y991A) mice

GenotypeNormal chow diet
High-fat diet
Wild typeY991AWild typeY991A
n 10 
Plasma free fatty acids (μmol · l−1 · ml−10.71 ± 0.23 0.44 ± 0.07 0.89 ± 0.15 0.61 ± 0.09 
Total cholesterol (mg/dl) 132.2 ± 5.9 130.0 ± 2.7 238.7 ± 10.5* 203.0 ± 27.9* 
Plasma triglycerides (mg/dl) 41.2 ± 2.5 42.7 ± 2.4 42.4 ± 2.6 46.6 ± 4.6 
MCP-1 (pg/ml) 22.0 ± 3.5 25.67 ± 6.1 43.25 ± 16.6 47.0 ± 20.5 
Adiponectin (μg · ml−1 · g−11.13 ± 0.22 1.37 ± 0.04 0.63 ± 0.05* 0.68 ± 0.03* 
Leptin (pg/ml) 3,699 ± 465 4,129 ± 723 14,038 ± 1,219* 10,222 ± 1,878* 
IL-6 (pg/ml) 0.63 ± 0.01 0.89 ± 0.09 1.51 ± 0.68 1.62 ± 0.44 
Resistin (pg/ml) 900.3 ± 60.6 1,104.3 ± 67.4 1,446.4 ± 108.6 1,270.8 ± 68.6 
TNF-α (pg/ml) 2.61 ± 0.28 2.41 ± 0.31 3.16 ± 0.27 3.28 ± 0.49 
GenotypeNormal chow diet
High-fat diet
Wild typeY991AWild typeY991A
n 10 
Plasma free fatty acids (μmol · l−1 · ml−10.71 ± 0.23 0.44 ± 0.07 0.89 ± 0.15 0.61 ± 0.09 
Total cholesterol (mg/dl) 132.2 ± 5.9 130.0 ± 2.7 238.7 ± 10.5* 203.0 ± 27.9* 
Plasma triglycerides (mg/dl) 41.2 ± 2.5 42.7 ± 2.4 42.4 ± 2.6 46.6 ± 4.6 
MCP-1 (pg/ml) 22.0 ± 3.5 25.67 ± 6.1 43.25 ± 16.6 47.0 ± 20.5 
Adiponectin (μg · ml−1 · g−11.13 ± 0.22 1.37 ± 0.04 0.63 ± 0.05* 0.68 ± 0.03* 
Leptin (pg/ml) 3,699 ± 465 4,129 ± 723 14,038 ± 1,219* 10,222 ± 1,878* 
IL-6 (pg/ml) 0.63 ± 0.01 0.89 ± 0.09 1.51 ± 0.68 1.62 ± 0.44 
Resistin (pg/ml) 900.3 ± 60.6 1,104.3 ± 67.4 1,446.4 ± 108.6 1,270.8 ± 68.6 
TNF-α (pg/ml) 2.61 ± 0.28 2.41 ± 0.31 3.16 ± 0.27 3.28 ± 0.49 

Data are means ± SE. n values per group are indicated.

*

Significant difference between diet within genotype. None of these parameters were statistically different between genotypes.

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